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Multiple births associated with assisted human reproduction in Canada
Jocelynn L Cook1, Leslie Geran2, Michelle Rotermann2
1Department of Obstetrics and Gynecology, University of Ottawa, Ottawa ON.
Journal of Obstetrics and Gynaecology Canada : JOGC = Journal D'Obstetrique Et Gynecologie Du Canada : JOGC
|August 18, 2011
Summary
Assisted reproduction and maternal age significantly contribute to multiple births in Canada, with higher impacts on triplets than twins. These findings aid in developing strategies for healthier pregnancies.
Area of Science:
- Reproductive Health
- Perinatology
- Public Health
Background:
- Assisted human reproduction (AHR) is linked to elevated multiple birth rates.
- Multiple pregnancies pose risks for infant and maternal health, straining healthcare systems.
- Canadian data on AHR's contribution to multiple births are lacking.
Purpose of the Study:
- To quantify the impact of maternal age and AHR on multiple birth rates in Canada.
- To differentiate contributions to twin versus triplet pregnancies.
Main Methods:
- Analysis of Canadian Vital Statistics: Births and Stillbirths data.
- Integration with the Canadian Assisted Reproductive Technologies Register.
- Application of a Centers for Disease Control and Prevention mathematical model, standardizing maternal age distributions to 1978.
Main Results:
- In vitro fertilization, ovulation induction, and maternal age have a greater influence on triplet rates compared to twin rates.
- Natural conception factors contribute more to twin births than to triplet births.
Conclusions:
- This study provides the first Canadian analysis differentiating the roles of age and AHR in multiple births.
- Findings can inform physician and patient education and guide treatment protocols for reduced-risk pregnancies.
- Improved understanding can lead to better long-term health outcomes for mothers and infants.
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