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Published on: December 10, 2013
[The study of human rhinovirus in infants with lower respiratory tract infections]
Huan-huan Wang1, Nai-ying Mao, Song-tao Xu
1Department of Neurobiology, Taishan Medical College, Taian 271000, China.
Insights
Human rhinovirus infections are common in Beijing infants, particularly those under two years old, leading to lower respiratory tract infections like pneumonia. This seasonal virus spreads quickly, necessitating hospital infection control measures.
Area of Science:
- Virology
- Pediatric Infectious Diseases
- Epidemiology
Context:
- Human rhinovirus (HRV) is a significant cause of respiratory illness in children.
- Understanding HRV prevalence and associated conditions in specific geographic areas is crucial for public health.
- Beijing experiences seasonal peaks in respiratory infections among its pediatric population.
Purpose:
- To investigate the prevalence and clinical characteristics of human rhinovirus (HRV) infections in hospitalized infants and children in Beijing.
- To determine the association between HRV and lower respiratory tract infections, including pneumonia.
- To identify the age groups most affected by HRV.
Summary:
- A study of 240 hospitalized children in Beijing found a 29.58% HRV positive rate using real-time reverse transcription PCR (RT-PCR).
- Pneumonia was the predominant diagnosis (86.67%), with most HRV cases occurring in children under two years old.
- HRV infections peaked in spring and winter, with highest incidence in infants aged 13-18 months and those 24 months and older.
Impact:
- This research highlights HRV as a key pathogen in pediatric lower respiratory tract infections in Beijing.
- Findings underscore the importance of age-specific vulnerability, with infants under two being the primary risk group.
- The study emphasizes the need for enhanced infection control protocols in healthcare settings to prevent HRV transmission.
Objective:
We want to explore the harm degree of human rhinovirus in infants in Beijing area.
Methods:
From May 2008 to September 2009, 240 nasopharyngeal aspirates were collected from the children and infants who were hospitalized and with lower respiratory tract infections. These specimens were screened for HRV by real-time reverse transcription PCR (RT-PCR) and statistically analysised.
Result:
In all of 240 hospitalized children, 208 cases were admission diagnosis of pneumonia, accounting for 86.67% (208/240), no deaths, the ratio of male and female patients was 1.93 : 1, and the collected samples reached to a maximum number in February 2009. Real-time PCR used to detect human rhinovirus, positive samples number is 71, positive rate is 29.58% (71/240), and the main symptoms and clinical diagnosis was pneumonia. Most cases were less than 2 years old, making up 81.69% (58/71), amony them, 13 months-18 months age and > or = 24 months groups have the highest incidence rates, the incidence rate is 33.33%.
Conclusion:
Human rhinovirus happened in spring and winter seasons, especially the infants who were under 2 years are the main infection groups, the important symptoms are lower respiratory infections such as pneumonia, bronchitis and bronchiolitis et al. Human rhinovirus is seasonal and contagious, spreads fast, so protective measures in hospitals should be prepared to avoid cross-infection.
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