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Updated: May 29, 2026

Isolation of Leukocytes from the Murine Tissues at the Maternal-Fetal Interface
Published on: May 21, 2015
[Fetal and neonatal alloimmune thrombocytopenia]
Ellen Birkerod Morling Taaning1, Jens Kjeldsen-Kragh, Morten Hedegaard
1Klinisk Immunologisk Afdeling, Vævstypelaboratoriet, Rigshospitalet, Tagensvej 20, 2200 København N, Denmark. ellen.morling.taaning@rh.regionh.dk
Abstract:
Fetal and neonatal alloimmune thrombocytopenia (FNAIT) may lead to intracranial haemorrhage (ICH) resulting in neurological damage or death. In FNAIT, transplacental maternal antibodies cause destruction of fetal platelets. Maternal immunisation occurs to fetal human platelet antigens (HPAs) inherited from the father. In the absence of screening the diagnosis often relies on a serious incident in a previous pregnancy or in a newborn sibling. Thus, a future reduction in the risk of ICH depends on prospective large trials to evaluate different diagnostic, treatment, and prevention strategies.
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