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Murine Intrapulmonary Tracheal Transplantation: A Model for Investigating Obliterative Airway Disease After Lung Transplantation
Published on: November 10, 2023
Coccidioidomycosis and lung transplantation
Holenarasipur R Vikram1, Amrita Dosanjh, Janis E Blair
1Division of Infectious Diseases, Mayo Clinic, Phoenix, AZ, USA.
Transplantation
|August 27, 2011
Summary
Coccidioidomycosis poses a significant risk to lung transplant candidates and recipients in endemic areas. This review proposes strategies for screening, treating, and preventing this fungal infection in vulnerable patients.
Area of Science:
- Mycology
- Infectious Diseases
- Transplantation Immunology
Background:
- Coccidioidomycosis is a fungal infection endemic to the southwestern US.
- Immunocompromised individuals, especially solid organ transplant recipients, face high morbidity and mortality.
- Lung transplant recipients are particularly vulnerable due to direct airway exposure and impaired lung defenses.
Purpose of the Study:
- To review current data on coccidioidomycosis in solid organ transplant candidates and recipients.
- To highlight the heightened risk of pulmonary coccidioidomycosis post-lung transplantation.
- To propose evidence-based strategies for screening, treatment, and prevention.
Main Methods:
- Comprehensive literature review of coccidioidomycosis in transplant populations.
- Analysis of risk factors unique to lung transplant recipients.
- Synthesis of existing guidelines and clinical data.
Main Results:
- Lung transplant recipients face increased risk due to physiological changes post-transplant.
- Early diagnosis and treatment are crucial for managing coccidioidomycosis in this population.
- Proactive screening and preventative measures are essential.
Conclusions:
- Lung transplant candidates and recipients require tailored management strategies for coccidioidomycosis.
- Multidisciplinary collaboration is key for effective prevention and treatment.
- Further research is needed to optimize care for this high-risk group.
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