Related Experiment Video
Updated: Mar 26, 2026

06:19
Author Spotlight: A Novel Protocol for Intracameral Injections to Enhance Precision in Rodent Ophthalmology
Published on: May 31, 2024
1.9K
Endothelial cell loss after small incision cataract surgery.
1Regional Institute of Ophthalmology, Kolkata, West Bengal, India. skdthakur@yahoo.com
Summary
Small incision cataract surgery (SICS) with posterior chamber intraocular lens (PC IOL) implantation results in a 15.83% reduction in corneal endothelial cell density. This cell loss is comparable to other cataract surgery methods.
Area of Science:
- Ophthalmology
- Corneal Science
- Surgical Outcomes
Background:
- The corneal endothelium is vital for corneal hydration and transparency.
- Cataract surgery invariably causes some endothelial cell loss, varying by technique.
Purpose of the Study:
- To assess central corneal endothelial cell density before and after small incision cataract surgery (SICS) with posterior chamber intraocular lens (PC IOL) implantation.
Main Methods:
- 100 eyes of 100 patients undergoing SICS with PC IOL were studied.
- Non-contact specular microscopy measured endothelial cell density pre-operatively and post-operatively (Day 1, Day 7, and 1 month).
Main Results:
- Pre-operative mean endothelial cell count was 2673 ± 358.85 cells/mm².
- Post-operative mean count at 1 month was 2249.77 ± 354.04 cells/mm².
Conclusions:
- SICS with PC IOL implantation led to a 15.83% reduction in endothelial cell count.
- This cell loss is comparable to extra-capsular cataract extraction and phacoemulsification.

