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Updated: May 29, 2026

Sequence-specific and Selective Recognition of Double-stranded RNAs over Single-stranded RNAs by Chemically Modified Peptide Nucleic Acids
Published on: September 21, 2017
Oligonucleotides decoy to NF-kappaB: becoming a reality?
1Department of Experimental Pharmacology, School of Biotechnological Sciences, University of Naples Federico II, Naples, Italy. dadestef@unina.it
Abstract:
In the last two decades, frontiers in new drug development are represented by genetic code inhibitors. Nuclear factor-kappaB (NF-κB) is a transcription factor playing critical roles in many inflammatory/immune diseases. Decoy oligonucleotides (decoy ONs) epitomize an ideal pharmacological tool to selectively block NF-κB activation. Their use is currently being investigated in several chronic inflammatory-based diseases. However, decoy ONs' clinical use is strongly hampered by several issues. Chemical modifications and/or delivery systems have been investigated to overcome some of these limits. This review describes the successful preclinical and clinical applications of decoy ON against NF-κB in inflammatory-based diseases.
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