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Updated: May 29, 2026

Recognition of Epidermal Transglutaminase by IgA and Tissue Transglutaminase 2 Antibodies in a Rare Case of Rhesus Dermatitis
Published on: December 15, 2011
[Diaper dermatitis]
R Fölster-Holst1, M Buchner, E Proksch
1Klinik für Dermatologie, Venerologie und Allergologie, Universitätsklinikum Schleswig-Holstein, Campus Kiel, Kiel, Deutschland. rfoelsterholst@dermatology.uni-kiel.de
Insights
Diaper dermatitis, a common infant skin condition, arises from irritant contact eczema due to prolonged diaper use. Proper skin care and frequent changes are key to managing this condition and preventing infections.
Area of Science:
- Dermatology
- Pediatrics
Context:
- Diaper dermatitis is a prevalent skin condition in infants and children.
- It stems from irritant contact eczema caused by urine, feces, and occlusive diaper conditions.
- Hyperhydration, pressure, and friction exacerbate the condition.
Purpose:
- To outline the causes and contributing factors of diaper dermatitis.
- To highlight the association with Candida albicans infection.
- To emphasize diagnostic approaches and therapeutic strategies.
Summary:
- Diaper dermatitis results from a complex interaction of irritants under occlusive diaper conditions.
- Candida albicans infections frequently complicate diaper dermatitis.
- Accurate diagnosis requires thorough skin examination, history, and potentially histology.
Impact:
- Frequent diaper changes and diligent skin care are crucial for therapeutic management.
- Understanding these factors aids in preventing and treating infant skin conditions effectively.
Abstract:
Diaper dermatitis is one of the most common skin diseases during infancy and childhood. It is a type of irritant contact eczema resulting from a complex interaction between urine and feces under occlusive conditions in combination with the hyperhydration of the stratum corneum, pressure and friction under the diaper. These conditions pave the way for Candida albicans infection, which is often associated with diaper dermatitis. The anogenital region can be involved by a variety of dermatoses, so a precise skin examination, detailed history and sometimes histologic examination are needed for a precise diagnosis. Therapeutically, frequent diaper changes and adequate skin care are most important.
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