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Synthesis of a Borylated Ibuprofen Derivative Through Suzuki Cross-Coupling and Alkene Boracarboxylation Reactions
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Synthesis of a Borylated Ibuprofen Derivative Through Suzuki Cross-Coupling and Alkene Boracarboxylation Reactions

Published on: November 30, 2022

A prospective, population-based study of acute ibuprofen overdose: complications are rare and routine serum levels

N E McElwee1, J C Veltri, D C Bradford

  • 1Intermountain Regional Poison Control Center, Salt Lake City, Utah 84132.

Annals of Emergency Medicine
|June 1, 1990
PubMed

Insights

Ibuprofen overdose is generally mild, with few severe symptoms. Measuring ibuprofen levels in the blood or using a nomogram does not reliably predict toxicity in overdose cases.

Area of Science:

  • Pharmacology
  • Toxicology
  • Emergency Medicine

Background:

  • Over-the-counter availability of ibuprofen necessitates understanding its acute toxicity.
  • Assessing ibuprofen overdose risks in the general population is crucial.

Purpose of the Study:

  • To evaluate the clinical outcomes of ibuprofen overdose.
  • To assess the predictive value of ibuprofen serum concentrations and a nomogram for toxicity.

Main Methods:

  • Prospective study of 329 ibuprofen overdose cases reported to a poison center.
  • Measurement of ibuprofen serum concentrations in 85 patients.
  • Evaluation of a previously published nomogram for predicting toxicity.

Main Results:

  • Gastrointestinal disturbances (42%) and CNS depression (30%) were common but mild.
  • Only one patient experienced severe symptoms attributable to ibuprofen.
  • Ibuprofen serum concentrations showed poor correlation with symptom severity and toxicity.
  • The nomogram had low predictive value for severe symptoms (6% overall, 0% for ibuprofen alone).

Conclusions:

  • Life-threatening complications from ibuprofen overdose are infrequent.
  • Routine serum concentration monitoring is not beneficial for managing overdose.
  • The evaluated nomogram is not a reliable predictor of ibuprofen toxicity.

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