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Updated: May 29, 2026
07:05
Ultrasound-guided Botulinum Toxin-A Injections: A Method of Treating Sialorrhea
Published on: November 9, 2016
Unilateral aquagenic keratoderma treated with botulinum toxin A
Marie-Claude Houle1, Rola Al Dhaybi, Antranik Benohanian
1Department of Dermatology, University of Montreal, Montreal, Quebec, Canada.
Journal of Dermatological Case Reports
|September 3, 2011
Summary
This study presents a unique case of unilateral aquagenic keratoderma, a rare skin condition. Botulinum toxin A injections effectively treated this idiopathic condition, suggesting a role for sweat glands.
Area of Science:
- Dermatology
- Rare Diseases
Background:
- Aquagenic keratoderma is a rare, transient skin condition triggered by water immersion.
- Its exact pathogenesis remains unclear, with few cases linked to medications.
Observation:
- A 60-year-old man presented with a 30-year history of aquagenic keratoderma affecting only his right palm.
- He had no history of hyperhidrosis or drug intake.
Findings:
- Standard treatment with 15% aluminium chloride hexahydrate gel was ineffective.
- Botulinum toxin A injections resulted in significant improvement within two weeks.
Implications:
- This is the first reported case of idiopathic unilateral aquagenic keratoderma.
- Successful treatment with botulinum toxin A supports the involvement of sweat glands in aquagenic keratoderma pathogenesis.
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