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Yeasts are single-celled organisms, but unlike bacteria, they are eukaryotes (cells with a nucleus). Cell signaling in yeast is similar to signaling in other eukaryotic cells. A ligand, such as a protein or a small molecule released from a yeast cell, attaches to a receptor on the cell surface. The binding stimulates second-messenger kinases to activate or inactivate transcription factors that further regulate gene expression. Many of the yeast intracellular signaling cascades have similar...

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Related Experiment Video

Updated: May 29, 2026

Quantifying Yeast Chronological Life Span by Outgrowth of Aged Cells

Quantifying Yeast Chronological Life Span by Outgrowth of Aged Cells

Published on: May 6, 2009

Gamete formation resets the aging clock in yeast.

E Ünal¹, A Amon

¹David H. Koch Institute for Integrative Cancer Research, Howard Hughes Medical Institute, Massachusetts Institute of Technology, Cambridge, Massachusetts 02142, USA.

Cold Spring Harbor Symposia on Quantitative Biology

|September 6, 2011

Summary

Rejuvenation occurs during gametogenesis in yeast, where aged cells clear damage. This process resets lifespan, enabling gametes from old cells to possess the same potential as those from young cells.

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Last Updated: May 29, 2026

Quantifying Yeast Chronological Life Span by Outgrowth of Aged Cells

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Published on: May 6, 2009

Continuous High-resolution Microscopic Observation of Replicative Aging in Budding Yeast

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Published on: August 20, 2013

Studying Age-dependent Genomic Instability using the S. cerevisiae Chronological Lifespan Model

Studying Age-dependent Genomic Instability using the S. cerevisiae Chronological Lifespan Model

Published on: September 29, 2011

Area of Science:

Cellular biology
Gerontology
Reproductive biology

Background:

Replicative aging leads to cellular damage accumulation.
Gametogenesis is crucial for sexual reproduction and genetic diversity.

Purpose of the Study:

To investigate if gametogenesis can reverse aging in yeast.
To explore mechanisms of rejuvenation during gamete formation.

Main Methods:

Studies were conducted on budding yeast (Saccharomyces cerevisiae).
Analysis of cellular damage in aged cells undergoing gametogenesis.
Assessment of replicative potential in gametes derived from young and aged cells.

Main Results:

Replicatively aged yeast cells successfully removed age-induced cellular damage during gametogenesis.
Gametes produced by aged cells exhibited equivalent replicative potential to gametes from young cells.
Lifespan appears to be reset during the gametogenesis process.

Conclusions:

Gametogenesis acts as a rejuvenation mechanism in budding yeast.
This process effectively eliminates accumulated cellular damage and resets lifespan.
Potential analogous mechanisms may exist in higher eukaryotes, offering insights into aging and reproduction.