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Updated: May 29, 2026

Drug Repurposing Hypothesis Generation Using the "RE:fine Drugs" System
Published on: December 11, 2016
Computing the compliance of physician drug orders with guidelines using an OWL2 reasoner and standard drug resources
Joseph Noussa Yao1, Brigitte Séroussi, Jacques Bouaud
1INSERM UMR_S 872, éq. 20, CRC, Paris, France.
Abstract:
Assessing the conformity of a physician's prescription to a given recommended prescription is not obvious since both prescriptions are expressed at different levels of abstraction and may concern only a subpart of the whole order. Recent formalisms (OWL2) and tools (reasoners) from the semantic web technologies are becoming available to represent defined concepts and to handle classification services. We propose a generic framework based on such technologies, using available standardized drug resources, to compute the compliance of a given drug order to a recommended prescription, such that the subsumption relationship yields the conformity relationship between the order and the recommendation. The ATC drug classification has been used as a local ontology. The method has been successfully implemented for arterial hypertension management for which we had a sample of antihypertensive orders. However, supplemental standardized drug knowledge is needed to correctly compare drug orders to recommended orders.
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