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The antimalarial ferroquine: from bench to clinic
1Unité de Catalyse et Chimie du Solide, CNRS UMR 8181, Université Lille Nord de France. christophe.biot@univ-lille1.fr
Abstract:
Ferroquine (FQ, SSR97193) is currently the most advanced organo-metallic drug candidate and about to complete phase II clinical trials as a treatment for uncomplicated malaria. This ferrocene-containing compound is active against both chloroquine-susceptible and chloroquine-resistant Plasmodium falciparum and P. vivax strains and/or isolates. This article focuses on the discovery of FQ, its antimalarial activity, the hypothesis of its mode of action, the current absence of resistance in vitro and recent clinical trials.
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