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Related Concept Videos

Glaucoma: Overview01:25

Glaucoma: Overview

Glaucoma is an eye condition characterized by increased intraocular pressure that damages the retina and optic nerve, leading to irreversible blindness if left untreated. The human eye has various components, including the cornea, iris, pupil, lens, and optic nerve. Aqueous humor is secreted by the epithelium of the ciliary body in the posterior chamber and flows through the trabecular meshwork and canal of Schlemm, maintaining normal intraocular pressure. The trabecular meshwork and the canal...
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Open Angle Glaucoma: Treatment

In open-angle glaucoma, the iridocorneal angle remains open, but the trabecular meshwork becomes stiff, slowing down the outflow of aqueous humor. This causes a buildup of aqueous humor in the anterior chamber, leading to a sudden increase in intraocular pressure. The treatment for open-angle glaucoma focuses on reducing the elevated intraocular pressure by either decreasing the secretion of aqueous humor or increasing its outflow.
Drugs such as carbonic anhydrase inhibitors, α2- and...
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Angle-closure glaucoma, or closed-angle glaucoma, is an eye condition where the iris bulges out and blocks the iridocorneal angle, resulting in a buildup of aqueous humor and increased intraocular pressure. Immediate medical attention is necessary due to the sudden onset of symptoms. The treatment for angle-closure glaucoma includes short-term and long-term approaches. Short-term treatment involves using eye drops like pilocarpine to lower intraocular pressure by increasing aqueous humor...
Diabetic Retinopathy01:27

Diabetic Retinopathy

DefinitionDiabetic retinopathy is a microvascular complication of diabetes affecting the retinal blood vessels.Risk FactorsDiabetic retinopathy is present in almost all individuals with type 1 diabetes and more than 60% of those with type 2 diabetes after two decades of disease.The risk increases with poor glycemic control, hypertension, dyslipidemia, smoking, pregnancy, and puberty.Although cataracts and glaucoma are also more frequent in people with diabetes, retinopathy remains the leading...

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Ex Vivo OCT-Based Multimodal Imaging of Human Donor Eyes for Research into Age-Related Macular Degeneration
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Ex Vivo OCT-Based Multimodal Imaging of Human Donor Eyes for Research into Age-Related Macular Degeneration

Published on: May 26, 2023

Indolent nonprogressive multifocal choroidal lesions.

Heather N Shelsta1, Lee M Jampol, David V Weinberg

  • 1Department of Ophthalmology, Northwestern University Feinberg School of Medicine, 645 North, Michigan Avenue, Suite 440, Chicago, IL 60611, USA. hshelsta@yahoo.com

Retina (Philadelphia, Pa.)
|September 9, 2011
PubMed
Summary
This summary is machine-generated.

This case series describes four patients with unexplained, nonprogressive yellow or white choroidal lesions. Advanced imaging suggests these lesions are localized to the choroid, potentially representing a new disease process.

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In Vivo Multimodal Imaging and Analysis of Mouse Laser-Induced Choroidal Neovascularization Model
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Area of Science:

  • Ophthalmology
  • Retinal Diseases
  • Choroidal Imaging

Background:

  • Presents a case series of four patients with unilateral, nonprogressive, yellow or white choroidal lesions of unknown etiology.
  • These patients were referred to an academic medical retina practice for unusual fundus findings.

Observation:

  • Comprehensive clinical examination and retinal imaging, including fluorescein angiography, indocyanine green imaging, and optical coherence tomography, were performed.
  • Extensive workups for differential diagnoses such as birdshot chorioretinopathy, lymphoma, metastases, and infections were negative.

Findings:

  • Key characteristics include absence of intraocular inflammation, late hypofluorescent staining on indocyanine green imaging, and late staining on fluorescein angiography.
  • Time-domain optical coherence tomography did not visualize lesions in the retina or retinal pigment epithelium.
  • Enhanced depth imaging spectral-domain optical coherence tomography indicated lesions localized to the choroid.

Implications:

  • The nonprogressive clinical course over prolonged observation suggests a stable condition.
  • These cases may represent atypical presentations of known retinal diseases or a novel chorioretinal disease.
  • Advanced imaging techniques like enhanced depth imaging spectral-domain optical coherence tomography are crucial for understanding these choroidal lesions.