Related Experiment Video
Updated: May 29, 2026
![Chemical-Induced Skin Carcinogenesis Model Using Dimethylbenz[a]Anthracene and 12-O-Tetradecanoyl Phorbol-13-Acetate (DMBA-TPA)](/_next/image?url=https%3A%2F%2Fcloudfront.jove.com%2FCDNSource%2Fteasers%2F60445.jpg&w=3840&q=50)
04:12
Chemical-Induced Skin Carcinogenesis Model Using Dimethylbenz[a]Anthracene and 12-O-Tetradecanoyl Phorbol-13-Acetate (DMBA-TPA)
Published on: December 19, 2019
[Cutaneous malignancies in occupationally-induced scars].
H C Broding1, A Köllner, T Brüning
1Abtl. für klinische & experimentelle Berufsdermatologie Institut für Prävention und Arbeitsmedizin der Deutschen Gesetzlichen Unfallversicherung (IPA), Institut der Ruhr-Universität Bochum, Bochum. broding@ipa.ruhr-uni-bochum.de
Summary
Neoplasms in occupational scars are challenging to compensate due to long latency and scar documentation issues. One of three evaluated cases met criteria for occupational disease, highlighting diagnostic complexities in scar-related neoplasms.
Area of Science:
- Occupational Dermatology
- Dermatopathology
- Forensic Medicine
Context:
- Statutory accident insurance regulations govern compensation for neoplasms arising in occupational scars.
- Emerging occupational dermatology guidelines establish criteria for recognizing scar-induced neoplasms and determining compensation eligibility.
Purpose:
- To re-evaluate medical opinions on neoplasms in potential occupational scars using German social accident insurance criteria and the Bamberg medical bulletin (BM II).
- To assess the qualification of these cases for recognition as occupational or accident-related disorders.
Summary:
- A retrospective analysis of 217 dermatological claim files (2007-2009) identified three cases of suspected neoplasms in occupationally-related scars.
- One case was approved as an occupational disease due to injury, resulting in reduced earning capacity, aligning with BM II guidelines.
- The other two cases did not meet the established criteria for compensation.
Impact:
- Highlights the difficulties in evaluating malignant tumors in occupational scars, primarily due to long latency periods and inadequate scar documentation.
- Recommends histological re-examination of tumor excision specimens to confirm the presence of an associated scar for accurate diagnosis and compensation.
Related Concept Videos
01:30Skin Cancer
Skin cancer is a type of cancer that occurs when there is an abnormal growth of skin cells, usually triggered by damage to the DNA within the skin cells. It is primarily caused by exposure to ultraviolet (UV) radiation from the sun or artificial sources like tanning beds. Skin cancer is the most common type of cancer worldwide, and its incidence continues to rise.
Basal Cell Carcinoma (BCC): BCC is the most common type of skin cancer, accounting for about 80% of cases. It typically develops in...
Basal Cell Carcinoma (BCC): BCC is the most common type of skin cancer, accounting for about 80% of cases. It typically develops in...
01:24Healing II: Complications
Complications during healing arise when tissue repair is altered by local or systemic factors. These changes involve abnormal collagen deposition, altered biomechanics, and reduced vascular supply, impairing restoration of normal structure and function.Loss of FunctionScar tissue differs significantly from the original tissue it replaces. In the skin, fibrosis lacks adnexal structures such as hair follicles, sebaceous glands, and sweat glands. Their absence reduces tactile sensitivity, impairs...
01:23Skin Diseases and Disorders
Skin is the first line of defense and encounters a variety of microbes. Some pathogenic strains are often the cause of a broad range of infections of the skin and other body systems. These conditions can affect people of all ages and may have different causes, including genetic factors, infections, autoimmune reactions, environmental factors, and lifestyle choices.
Gram-positive Staphylococcus spp. and Streptococcus spp. are responsible for many of the most common skin infections. However, many...
Gram-positive Staphylococcus spp. and Streptococcus spp. are responsible for many of the most common skin infections. However, many...
01:22Burn Injuries
Burn injuries occur when the skin and underlying tissues are damaged due to exposure to heat, electricity, chemicals, radiation, or friction. They can vary in severity, from minor superficial burns to severe deep burns that can be life-threatening.
The damage results in the death of skin cells, which can lead to a massive loss of fluid. Dehydration, electrolyte imbalance, and renal and circulatory failure follow, which can be fatal. Burn patients are treated with intravenous fluids to offset...
The damage results in the death of skin cells, which can lead to a massive loss of fluid. Dehydration, electrolyte imbalance, and renal and circulatory failure follow, which can be fatal. Burn patients are treated with intravenous fluids to offset...
01:19Clinical Applications of Epidermal Stem Cells
Epidermal stem cells (EpiSCs) are mainly located at the basal layer of the epidermis. These cells repair minor injuries of the skin and replace dead skin cells. However, EpiSCs’ cannot heal severe wounds such as major burns or those from diabetes or hereditary disorders. In such cases, culturing the epidermal stem cells from the patient is possible and has yielded successful treatment options, such as laboratory-grown skin grafts. These grafts are synthesized using a patient’s own EpiSCs...