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Sterile Pericarditis in Aachener Minipigs As a Model for Atrial Myopathy and Atrial Fibrillation
Published on: September 24, 2021
[Pericarditis and cardiac tamponade: urgent condition not only in cardiology]
Dejan Sakac1, Dragan V Kovacević, Goran Koraćević
1Institut za kardiovaskularne bolesti Vojvodine, Sremska Kamenica. dejsakac@open.telekom.rs
Insights
Pericarditis, inflammation of the pericardium, can lead to cardiac tamponade. Prompt diagnosis and treatment, including pericardiocentesis and medications like colchicine, are crucial for preventing fatal outcomes.
Area of Science:
- Cardiology
- Internal Medicine
- Pathophysiology
Context:
- Pericarditis involves inflammation of the pericardium, with diverse causes including viral infections, neoplasms, and autoimmune diseases.
- While often inflammatory, pericarditis can be non-infective and presents in acute, chronic, or relapsing forms.
- Identifying the underlying cause of pericarditis is essential for effective management.
Purpose:
- To highlight the potential for pericardial effusion and cardiac tamponade in patients with various underlying conditions.
- To emphasize the critical importance of early detection and intervention for pericardial effusion and cardiac tamponade.
- To discuss current therapeutic strategies for pericarditis, including anti-inflammatory medications and colchicine.
Summary:
- Pericarditis, inflammation of the pericardial sac, can lead to fluid accumulation (pericardial effusion) potentially causing cardiac tamponade, a life-threatening condition.
- Cardiac tamponade is characterized by hypotension, tachycardia, and muffled heart sounds, often diagnosed via echocardiography.
- Prompt diagnosis and treatment, such as pericardiocentesis and pharmacological therapy (NSAIDs, colchicine), are vital for improving patient outcomes.
Impact:
- Timely recognition and management of pericarditis and its complications can prevent fatal outcomes.
- Understanding the diverse etiologies of pericarditis guides diagnostic and therapeutic approaches.
- The integration of colchicine into standard therapy represents an advancement in managing pericarditis.
Introduction:
Pericarditis is a condition with inflammation of the pericardium; however, most of these conditions are not infective and many of them are not even inflammatory. Pericarditis by its development can be acute, sub-acute and chronic, and later, recurring or relapsing. Apart from idiopathic, the causes of pericarditis are numerous, very often inflammatory, most frequently caused by viruses, or tumours and neoplasms, diseases of connective tissue, vasculitis, different allergic reactions, radiation, thyroid gland diseases, uraemia, dissection of aorta etc.
Clinical Picture:
Accumulation of fluid in the pericardium in the amount sufficient to cause significant obstruction of blood inflow in chambers can cause cardiac tamponade. If it is not treated immediately, the outcome may be fatal. The most common causes are tumours, viruses or uraemia. Cardiac tamponade should be suspected in patients with a decrease in systemic arterial pressure or presence of hypotension, tachycardia, silent and discreet heart beats, increase in systemic venous pressure (Beck triad). Electrocardiogram may result in tachycardia, QRS complex is of smaller voltage, often of reversed polarity. The amount of effusion is estimated by echocardiography
Conclusion:
The cause of pericarditis should always be searched for. On the other hand, during monitoring or treatment of numerous conditions which could be a frequent cause of pericarditis, the presence of pericardial effusion or cardiac tamponade should be suspected and detected in due time. A timely intervention--pericardiocentesis, can prevent the fatal outcome. Besides non-steroid anti-inflammatory medication, many prospective randomised studies propose colchicine as addition to the standard therapy. When opting for the proper treatment for pericarditis always keep in mind the current diagnosis and cause of this condition.
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