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An HS-MRM Assay for the Quantification of Host-cell Proteins in Protein Biopharmaceuticals by Liquid Chromatography Ion Mobility QTOF Mass Spectrometry
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An HS-MRM Assay for the Quantification of Host-cell Proteins in Protein Biopharmaceuticals by Liquid Chromatography Ion Mobility QTOF Mass Spectrometry

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High-flow multiplexed MRM-based analysis of proteins in human plasma without depletion or enrichment

Dominik Domanski1, Derek S Smith, Christine A Miller

  • 1University of Victoria-Genome BC Proteomics Centre, Vancouver Island Technology Park, #3101-4464 Markham Street, Victoria, BC V8Z 7X8, Canada.

Clinics in Laboratory Medicine
|September 13, 2011
PubMed
Abstract

No abstract available in PubMed .

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A proteome is the entire set of proteins that a cell type produces. We can study proteomes using the knowledge of genomes because genes code for mRNAs, and the mRNAs encode proteins. Although mRNA analysis is a step in the right direction, not all mRNAs are translated into proteins.
Proteomics is the study of proteomes' function. It involves the large-scale systematic study of the proteome to denote the protein complement expressed by a genome. Scientist Mark Wilkins coined the term proteomics...