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Chronic Imaging of Mouse Visual Cortex Using a Thinned-skull Preparation

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Published on: October 25, 2010

Automatic cortical thickness analysis on rodent brain.

Joohwi Lee¹, Cindy Ehlers, Fulton Crews

¹Department of Computer Science, University of North Carolina, Chapel Hill NC, USA.

Proceedings of Spie--The International Society for Optical Engineering

|September 13, 2011

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This study presents a novel algorithm for accurately measuring rodent brain cortical thickness. The method reveals significant cortical differences in rats exposed to adolescent intermittent ethanol, impacting adult brain structure.

Area of Science:

Neuroscience
Computational Biology
Medical Imaging

Background:

Cortical thickness is a key morphometric trait in brain studies.
Existing human brain analysis tools are unsuitable for smaller rodent brains due to scale differences.

Purpose of the Study:

To develop and validate an algorithm for automatic cortical thickness measurement in mouse and rat brains.
To assess the persistent effects of adolescent intermittent ethanol exposure on adult rat cortical thickness.

Main Methods:

Algorithm involves neocortex segmentation, thickness measurement via Laplacian PDE and transport equations, and statistical analysis.
Particle correspondence algorithm with thin-plate spline interpolation ensures accurate point-wise thickness comparison.
T-test used to compare cortical thickness between control and ethanol-exposed rat groups.

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Main Results:

Successfully developed an automated algorithm for rodent cortical thickness mapping.
Identified significantly different cortical thickness regions in both hemispheres of ethanol-exposed rats.
Demonstrated the algorithm's utility in neurodevelopmental toxicology studies.

Conclusions:

The new algorithm provides a scalable solution for rodent brain morphometry.
Adolescent intermittent ethanol exposure leads to persistent, localized changes in adult rat cortical thickness.
This tool aids in understanding the long-term neurobiological consequences of early-life exposures.