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Published on: February 9, 2011

Intravenous device associated blood stream staphylococcal infection in paediatric patients

Amita Jain1, Astha Agarwal, Raj Kumar Verma

  • 1Department of Microbiology, Chhatrapati Shahuji Maharaj Medical University, Lucknow, India.

The Indian Journal of Medical Research
|September 14, 2011
PubMed

Insights

Staphylococci are a major cause of hospital-acquired bloodstream infections in children. Intravenous device (IVD) use significantly increases infection risk, with most S. epidermidis and S. haemolyticus infections linked to IVDs.

Area of Science:

  • Medical Microbiology
  • Infectious Diseases
  • Hospital Epidemiology

Background:

  • Staphylococcal bloodstream infections (BSIs) are a significant cause of morbidity and mortality in hospitalized patients.
  • Intravenous devices (IVDs) are common sources of nosocomial infections.

Purpose of the Study:

  • To determine the frequency of staphylococcal IVD-associated infections in a pediatric ward.
  • To assess antimicrobial resistance patterns of hospital-acquired staphylococcal isolates.

Main Methods:

  • Children with IVDs for over 48 hours were enrolled.
  • Blood, IVD tips, skin, and nasal swabs were collected and cultured.
  • Staphylococcal isolates underwent antimicrobial susceptibility testing and genotyping.

Main Results:

  • Staphylococcus aureus was the most frequent blood isolate (8.7%).
  • Microorganism isolation from blood was higher when skin, IVD, and nose were colonized by the same organism (P<0.001).
  • High resistance to penicillin and oxacillin was observed in both S. aureus and CoNS.

Conclusions:

  • Staphylococci are the primary cause of nosocomial BSIs in this pediatric cohort.
  • All S. epidermidis and S. haemolyticus BSIs were IVD-associated.
  • Only one-third of S. aureus BSIs were associated with IVD use.
Abstract

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