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Drug-Induced Sleep Endoscopy (DISE) with Target Controlled Infusion (TCI) and Bispectral Analysis in Obstructive Sleep Apnea
07:54

Drug-Induced Sleep Endoscopy (DISE) with Target Controlled Infusion (TCI) and Bispectral Analysis in Obstructive Sleep Apnea

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Management of obstructive sleep apnea associated with Down syndrome and other craniofacial dysmorphologies

Dennis Rosen1

  • 1Division of Respiratory Diseases, Center for Pediatric Sleep Disorders, Children's Hospital Boston, Harvard Medical School, Boston, Massachusetts 02115, USA. dennis.rosen@childrens.harvard.edu

Current Opinion in Pulmonary Medicine
|September 16, 2011
PubMed

Insights

Screening for obstructive sleep apnea (OSA) in children with Down syndrome is crucial. Advances in imaging and surgical techniques offer new treatment options beyond traditional methods.

Area of Science:

  • Pediatric Sleep Medicine
  • Genetics and Rare Diseases
  • Craniofacial Surgery

Background:

  • Obstructive sleep apnea (OSA) is highly prevalent in children with Down syndrome and craniofacial abnormalities, leading to adverse physical, developmental, and behavioral effects.
  • Treatment of OSA in this population is challenging due to higher risks of surgical complications and lower success rates with adenotonsillectomy.

Purpose of the Study:

  • To review the current landscape of OSA treatment in children with Down syndrome and craniofacial abnormalities.
  • To highlight emerging treatment modalities and diagnostic advancements for this specific patient group.

Main Methods:

  • Review of current literature on OSA management in children with Down syndrome.
  • Emphasis on advanced imaging techniques like dynamic cine MRI for precise obstruction localization.
  • Discussion of alternative and advanced surgical and non-surgical interventions.

Main Results:

  • Several alternative treatment options are emerging, offering viable alternatives to continuous positive airway pressure (CPAP) and tracheostomy.
  • Dynamic cine MRI enables precise identification of the obstruction level, facilitating targeted treatment strategies.
  • Improved understanding of the unique challenges in treating OSA in this population.

Conclusions:

  • Increased screening for OSA in children with Down syndrome and craniofacial abnormalities is recommended.
  • Leveraging recent innovations in diagnostic imaging and surgical techniques can improve treatment outcomes for pediatric OSA.
Abstract

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