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Related Experiment Video

Updated: May 29, 2026

Isolation of Neonatal Extrahepatic Cholangiocytes

Isolation of Neonatal Extrahepatic Cholangiocytes

Published on: June 5, 2014

Neonatal jaundice.

Paul Woodgate¹, Luke Anthony Jardine

¹Department of Neonatology, Mater Mother's Hospital, Brisbane, Australia.

BMJ Clinical Evidence

|September 17, 2011

Summary

This summary is machine-generated.

This review examines treatments for newborn jaundice, a common condition caused by bilirubin buildup. It assesses the effectiveness and safety of interventions like phototherapy and exchange transfusion for infants.

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Area of Science:

Neonatal Medicine
Pediatrics
Clinical Evidence

Background:

Neonatal jaundice affects 50% of term and 80% of preterm infants.
Jaundice results from bilirubin deposition, often due to increased red blood cell breakdown or decreased bilirubin excretion.
Typically, jaundice appears 2-4 days after birth and resolves within 1-2 weeks.

Purpose of the Study:

To systematically review treatments for unconjugated hyperbilirubinemia in term and preterm infants.
To evaluate the effectiveness and safety of various interventions for neonatal jaundice.

Main Methods:

Conducted a systematic review of medical literature up to February 2010.
Searched databases including Medline, Embase, and The Cochrane Library.
Included harms alerts from regulatory agencies like the FDA and MHRA.

Main Results:

Included 42 systematic reviews, randomized controlled trials (RCTs), and observational studies.
Performed a GRADE evaluation to assess the quality of evidence for each intervention.

Conclusions:

Presents findings on the effectiveness and safety of albumin infusion, exchange transfusion, home phototherapy, immunoglobulin, hospital phototherapy, and tin-mesoporphyrin.
Provides evidence-based information for managing neonatal jaundice.