Corneal hysteresis and Beta-zone parapapillary atrophy

To evaluate the relationship between β-zone parapapillary atrophy (βPPA) and corneal hysteresis (CH) in patients with glaucoma.

Prospective, cross-sectional study.

Glaucoma patients aged 18 to 90 years with disc photographs within 12 months of the study visit were consecutively enrolled. Exclusion criteria included ocular surgery other than clear corneal phacoemulsification, myopia >6 diopters, contact lens use, and corneal abnormality. CH was measured using the Ocular Response Analyzer (ORA). Disc photographs were evaluated in a masked fashion for βPPA.

We enrolled 99 patients (mean age 67.6 years; 45 men, 54 women). Univariate analysis showed no significant difference in CH between eyes with and without βPPA (8.72 ± 0.23 vs 8.15 ± 0.27 mm Hg, P = .11). There were no differences in corneal resistance factor (CRF) (P = .47), central corneal thickness (CCT) (P = .11), ORA wave score (P = .23), age (P = .23), sex (P = .40), IOP (P = .86), or visual field mean deviation (VFMD) (P = .45). Eyes with βPPA were more myopic (-1.49 ± 0.27 vs -0.22 ± 0.31 diopters, P = .003). Multivariate analysis showed no significant difference in CH between eyes with and without βPPA (P = .38). Eyes with asymmetric βPPA also showed no significant difference in CH (8.97 ± 0.22 vs 9.10 ± 0.22 mm Hg, P = .69).

We found no significant differences in CH between eyes with and without βPPA or between fellow eyes with asymmetric βPPA.