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Published on: August 6, 2019
Matrix metalloproteinase 8 (MMP8) gene polymorphisms in chronic periodontitis.
L Izakovicova Holla1, B Hrdlickova, J Vokurka
1Clinic of Stomatology, Masaryk University Brno, Czech Republic. holla@med.muni.cz
Archives of Oral Biology
|September 17, 2011
Summary
This study found a specific MMP8 gene haplotype associated with chronic periodontitis risk in the Czech population, though individual gene variants were not linked. Further research on matrix metalloproteinase gene polymorphisms is warranted.
Area of Science:
- Genetics and Periodontology
- Molecular Biology of Periodontal Disease
Background:
- Matrix metalloproteinase (MMP) gene polymorphisms have been linked to periodontal disease risk.
- No prior studies have investigated MMP8 gene variants in relation to chronic periodontitis (CP).
Purpose of the Study:
- To analyze MMP8 gene polymorphisms and their association with the microbial composition and clinical presentation of CP.
- To investigate the role of specific MMP8 gene variants in the susceptibility to chronic periodontitis.
Main Methods:
- Genotyping of two MMP8 polymorphisms (-799C/T and +17C/G) using PCR-RFLP in 341 CP patients and 278 controls.
- Analysis of subgingival bacterial colonization in a subset of subjects (N=169).
Main Results:
- No significant differences in allele or genotype frequencies for individual MMP8 polymorphisms between CP patients and controls.
- A specific haplotype T(-799)/C(+17) was found to be significantly more frequent in CP patients (43.7%) compared to controls (37.6%).
- No significant associations were identified between periodontal pathogens, MMP8 polymorphisms, and CP.
Conclusions:
- Individual single nucleotide polymorphisms (SNPs) in the MMP8 gene were not directly associated with periodontitis.
- A specific haplotype within the MMP8 gene demonstrated an association with the clinical manifestation of chronic periodontitis in the Czech population.
