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Allostery in GPCRs: 'MWC' revisited

Meritxell Canals1, Patrick M Sexton, Arthur Christopoulos

  • 1Drug Discovery Biology, Monash Institute of Pharmaceutical Sciences and Department of Pharmacology, Monash University, Australia.

Trends in Biochemical Sciences
|September 17, 2011
PubMed
Summary

G protein-coupled receptors (GPCRs), targeted by many medicines, are increasingly understood through allosteric modulation. This review revisits the Monod-Wyman-Changeux (MWC) model to explain emerging GPCR allostery data.

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