Related Experiment Video

Updated: May 29, 2026

A Murine Model of Fetal Exposure to Maternal Inflammation to Study the Effects of Acute Chorioamnionitis on Newborn Intestinal Development
08:50

A Murine Model of Fetal Exposure to Maternal Inflammation to Study the Effects of Acute Chorioamnionitis on Newborn Intestinal Development

Published on: June 24, 2020

[Intestinal inflammation-induced child growth failure: immunologic and endocrine mechanisms]

Jing-Qiu Ma1, Xiao-Yang Sheng

  • 1Department of Child and Adolescent Health Care, Shanghai Jiao Tong University School of Medicine, China.

Zhongguo Dang Dai Er Ke Za Zhi = Chinese Journal of Contemporary Pediatrics
|September 20, 2011
PubMed

Insights

Children with intestinal inflammation often experience stunted linear growth. Inflammatory cytokines may disrupt the growth hormone/insulin-like growth factor-1 axis, impairing bone growth.

Area of Science:

  • Pediatric endocrinology
  • Gastroenterology
  • Inflammation research

Context:

  • Children with intestinal inflammation frequently exhibit faltering linear growth.
  • Growth hormone (GH) and insulin-like growth factor-1 (IGF-1) are critical for postnatal longitudinal bone growth.
  • Disruption of the GH/IGF axis leads to growth failure in pediatric populations.

Purpose:

  • To investigate the impact of intestinal inflammation on the growth hormone/insulin-like growth factor-1 axis.
  • To explore the role of pro-inflammatory cytokines in growth impairment associated with intestinal inflammation.

Summary:

  • Children with intestinal inflammation show elevated levels of pro-inflammatory cytokines like interleukin-1β (IL-1β), tumor necrosis factor-α (TNF-α), and interleukin-6 (IL-6).
  • These cytokines may systemically and locally affect the growth plate, interfering with the GH/IGF axis.
  • This interference contributes to the observed growth failure in affected children.

Impact:

  • Provides insight into the mechanisms underlying growth deficits in pediatric intestinal inflammatory diseases.
  • Highlights the GH/IGF axis as a potential therapeutic target for growth restoration.
  • Enhances understanding of the systemic effects of chronic inflammation on skeletal development.

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