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Related Concept Videos

Fractures: Bone Repair01:27

Fractures: Bone Repair

Treatment for a fracture is based on the type of break, the bone affected, and the patient's age.
Minor fractures with no bone displacement are treated by immobilizing the fractured bone using a cast or splint. However, in the case of fractures with displaced bones, the broken bones are repositioned before immobilization to ensure successful healing without deformation and loss of function. The realignment of fractured bone ends is performed through a process called reduction. If the procedure...
Pharmacokinetics in Pediatric Patients: Drug Distribution01:17

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Drug distribution in the pediatric population exhibits unique challenges and considerations due to the physiological differences between children, particularly neonates and infants, and adults. A crucial aspect of pediatric pharmacology is understanding how these differences impact the pharmacokinetics of various drugs, necessitating age-specific dosing strategies to ensure efficacy and safety.Neonates and infants have a higher total body water content, ~75%–90% of their body weight, compared...
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Understanding the physiological differences in the pediatric population is crucial for effective pharmacotherapy. Neonates, infants, and children exhibit significant variations in gastric pH, gastric emptying time, intestinal transit time, and biliary function. These variations profoundly affect oral drug absorption, necessitating a nuanced approach to pediatric dosing.Neonates present with a unique physiological profile, having a gastric pH greater than 4 and faster and more irregular gastric...
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In pediatric medicine, understanding the renal function and drug elimination nuances is crucial for administering safe and effective treatments. Newborns, in particular, display markedly slower renal functions than adults, profoundly affecting how drugs are cleared from their bodies. This slower drug clearance requires clinicians to extend the dosing intervals for many medications to prevent drug accumulation and toxicity while ensuring therapeutic efficacy.One key area where these adjustments...
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Related Experiment Video

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Development of a Novel Internal Fixation Model for Rat Radial Fractures: Fracture Healing Assessment and Dorsal Root Ganglion Isolation
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Pediatric Chance fractures: a multicenter perspective.

Alexandre Arkader1, William C Warner, Vernon T Tolo

  • 1Childrens Orthopaedic Center, Childrens Hospital Los Angeles, CA, USA. aarkader@chla.usc.edu

Journal of Pediatric Orthopedics
|September 20, 2011
PubMed
Summary

Surgical treatment of pediatric Chance fractures leads to better clinical outcomes. Proper use of restraints significantly reduces the risk of permanent neurological deficits in children with spinal injuries.

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Development of a Novel Internal Fixation Model for Rat Radial Fractures: Fracture Healing Assessment and Dorsal Root Ganglion Isolation
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Creating Rigidly Stabilized Fractures for Assessing Intramembranous Ossification, Distraction Osteogenesis, or Healing of Critical Sized Defects
07:35

Creating Rigidly Stabilized Fractures for Assessing Intramembranous Ossification, Distraction Osteogenesis, or Healing of Critical Sized Defects

Published on: April 11, 2012

Area of Science:

  • Orthopedic Surgery
  • Pediatric Traumatology
  • Spinal Injury Management

Background:

  • Chance fractures (flexion-distraction injuries) are rare in children.
  • Previous research on pediatric Chance fractures is limited to small case series.
  • This study represents the largest reported series in English literature.

Purpose of the Study:

  • To analyze the demographics, causes, treatment, and outcomes of pediatric Chance fractures.
  • To evaluate the effectiveness of surgical versus non-operative treatment.
  • To determine the impact of restraints on neurological deficits.

Main Methods:

  • Multicenter retrospective review of 35 pediatric patients (<18 years) with Chance fractures.
  • Analysis of injury patterns, treatment strategies (surgical vs. non-operative), complications, and clinical outcomes.
  • Comparative analysis of outcomes based on treatment type and restraint use.

Main Results:

  • Surgically treated patients showed less post-treatment kyphotic deformity (3.5° vs. 20°) and a higher rate of good clinical outcomes (84% vs. 45%).
  • Restrained patients had a significantly lower incidence of permanent neurological deficit (10% vs. 42%).
  • Complications included hardware discomfort in the surgical group and kyphosis progression in the non-operative group.

Conclusions:

  • Surgical intervention appears to yield better clinical outcomes for pediatric Chance fractures.
  • Appropriate use of restraints is crucial in reducing permanent neurological deficits.
  • This study provides valuable insights into managing these rare pediatric spinal injuries.