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Updated: May 29, 2026

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Published on: March 10, 2026
Lymphomatosis cerebri: clinical characteristics, neuroimaging, and pathological findings
Ryuhei Kitai1, Norichika Hashimoto, Kouji Yamate
1Department of Neurosurgery, Faculty of Medical Sciences, University of Fukui, Fukui, Japan. kitai@u-fukui.ac.jp
Abstract:
Lymphomatosis cerebri is a rare variant of primary central nervous system lymphoma. We present a case involving a 56-year-old immunocompetent woman who complained of rapid deterioration of her higher brain function over a 4-month period. Magnetic resonance imaging showed extensive white-matter lesions. During brain biopsy, a diffusely infiltrating lymphoma with distinctive immunohistochemical features was detected. Awareness of this unique presentation and early tissue diagnosis provide the best hope for instituting appropriate treatments.
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