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Stability of [(N-morpholine)metylene]daunorubicin hydrochloride in solid state
Przemysław Zalewski1, Anna Jelińska, Patrycja Prusinowska
1Department of Pharmaceutical Chemistry, Faculty of Pharmacy, Poznaxi University of Medical Sciences, 6 Grunwaldzka St., 60-780 Poznań, Poland pzalewski@ump.edu.pl
Abstract:
The influence of temperature and relative air humidity on the stability of the novel derivative of daunorubicin: [(N-morpholine)metylene]daunorubicin hydrochloride was investigated. The process of degradation was studied by using high-performance liquid chromatography with ultraviolet (UV) detection. In dry air, the degradation of [(N-morpholine)metylene]daunorubicin hydrochloride was a first-order reaction depending on the substrate concentration, while at relative air humidity from 60.5 to 90.0% it was an autocatalytic reaction of the first order with respect to MMD concentration. The kinetic and thermodynamic parameters of degradation were calculated.
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