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Long-term Depression

Long-term Depression

Long-term depression, or LTD, is one of the ways by which synaptic plasticity—changes in the strength of chemical synapses—can occur in the brain. LTD is the process of synaptic weakening that occurs over time between pre and postsynaptic neuronal connections. The synaptic weakening of LTD works in opposition to synaptic strengthening by long-term potentiation (LTP) and together are the main mechanisms that underlie learning and memory.
Calcium Ion Concentration Mechanism
If over time, all...

Long-term Depression

Long-term Depression

Long-term depression, or LTD, is one of the ways by which synaptic plasticity—changes in the strength of chemical synapses—can occur in the brain. LTD is the process of synaptic weakening that occurs over time between pre and postsynaptic neuronal connections. The synaptic weakening of LTD works in opposition to synaptic strengthening by long-term potentiation (LTP) and together are the main mechanisms that underlie learning and memory.

Depression: Overview

Depression: Overview

Depression is a prevalent mental illness marked by persistent sadness and lack of interest in previously enjoyable activities. It can take several forms, including major depression, persistent depressive disorder, and bipolar I and II disorders. Symptoms range from emotional changes like chronic worry to physical changes like sleep disturbances and suicidal thoughts. From a neurobiological perspective, depression is believed to be triggered by abnormalities in the brain's prefrontal cortex,...

Depressive Disorders: Etiology

Depressive Disorders: Etiology

Depressive disorders result from a complex interplay of biological, psychological, and sociocultural factors, each contributing uniquely to the development and persistence of the condition. Understanding these factors provides critical insight into the multifaceted nature of depression.
Biological Factors in Depression
Biological predispositions significantly influence the risk of developing depressive disorders. Genetic studies highlight the role of variations in the serotonin transporter...

Depressive Disorders: MDD and Dysthymia

Depressive Disorders: MDD and Dysthymia

Depressive disorders are a group of mental health conditions characterized by pervasive feelings of sadness, diminished pleasure in life, and a significant impact on daily functioning. These conditions are most prevalent in individuals during their 30s and affect women at twice the rate of men. Contrary to popular belief, younger individuals are generally more susceptible to these disorders than older adults. Two key types of depressive disorders include Major Depressive Disorder (MDD) and...

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Related Experiment Video

Updated: May 29, 2026

Cellular Membrane Affinity Chromatography Columns to Identify Specialized Plant Metabolites Interacting with Immobilized Tropomyosin Kinase Receptor B

Cellular Membrane Affinity Chromatography Columns to Identify Specialized Plant Metabolites Interacting with Immobilized Tropomyosin Kinase Receptor B

Published on: January 19, 2022

[Research progress of BDNF and depression].

Hui Qiao¹, Shu-Cheng An, Chang Xu

¹College of Life Science, Shanxi Normal University, Xian 710062, China.

Sheng Li Ke Xue Jin Zhan [Progress in Physiology]

|September 22, 2011

Summary

Brain-Derived Neurotrophic Factor (BDNF) plays a crucial role in nerve repair and is increasingly studied for its effects on neural plasticity in depression. Further research into BDNF interactions is expected to advance antidepressant mechanisms.

More Related Videos

Animal Models of Depression - Chronic Despair Model (CDM)

Animal Models of Depression - Chronic Despair Model (CDM)

Published on: September 23, 2021

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Last Updated: May 29, 2026

Cellular Membrane Affinity Chromatography Columns to Identify Specialized Plant Metabolites Interacting with Immobilized Tropomyosin Kinase Receptor B

Cellular Membrane Affinity Chromatography Columns to Identify Specialized Plant Metabolites Interacting with Immobilized Tropomyosin Kinase Receptor B

Published on: January 19, 2022

Animal Models of Depression - Chronic Despair Model (CDM)

Animal Models of Depression - Chronic Despair Model (CDM)

Published on: September 23, 2021

Area of Science:

Neuroscience
Molecular Biology
Psychiatry

Context:

Brain-Derived Neurotrophic Factor (BDNF) is prevalent in the central and peripheral nervous systems.
BDNF is vital for nerve regeneration and restoration.
Its role in neural plasticity is a key focus in depression research.

Purpose:

To review current findings and research trends on the relationship between BDNF and depression.
To explore the mechanisms underlying the effects of BDNF on antidepressant actions.

Summary:

BDNF influences neural plasticity, impacting depression development and antidepressant efficacy.
Research highlights the interaction between BDNF, its precursor proBDNF, and neurotransmitter systems.
Understanding these interactions is crucial for developing novel antidepressant strategies.

Impact:

This review consolidates current knowledge on BDNF's role in depression.
It identifies key areas for future research, particularly concerning BDNF interactions.
Findings may guide the development of more effective depression treatments.