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Related Experiment Video

Updated: May 29, 2026

Tissue Characterization after a New Disaggregation Method for Skin Micro-Grafts Generation
09:30

Tissue Characterization after a New Disaggregation Method for Skin Micro-Grafts Generation

Published on: March 4, 2016

Pyoderma chronica vegetans treated with mesh skin grafting.

Jaka Radoš1, Zrinjka Paštar, Franjo Rudman

  • 1Department of Dermatology and Venereology, University Hospital Center Zagreb, School of Medicine University of Zagreb, Croatia. sodarakaj@yahoo.com

Acta Dermatovenerologica Croatica : ADC
|September 22, 2011
PubMed
Summary
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Acta clinica Croatica·2025

Pyoderma chronica vegetans, a rare skin condition, presented as extensive lesions in a 72-year-old man. Surgical excision and skin grafting were effective treatments, showing no recurrence post-operation.

Area of Science:

  • Dermatology
  • Immunology

Background:

  • Pyoderma chronica vegetans is a rare disorder characterized by verrucous plaques and pustules, potentially linked to immune dysfunction.
  • The exact etiology remains unknown, but immune system dysfunction or immunosuppression is suspected.

Observation:

  • A 72-year-old male presented with extensive pyoderma chronica vegetans on the buttocks, including fistulas, scarring, and verrucous plaques.
  • Laboratory findings revealed elevated erythrocyte sedimentation rate, anemia, leukocytosis with a left shift, and polyclonal hyperglobulinemia.
  • Histopathology showed epidermal hyperplasia, sinus and abscess formation, fibrosis, and a mixed inflammatory infiltrate.

Findings:

  • Tissue cultures identified Streptococcus species and Escherichia coli.
  • T-cell functional tests indicated decreased responsiveness to mitogens, while monocyte and granulocyte phagocytic capabilities were normal.

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Murine Full-thickness Skin Transplantation
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Murine Full-thickness Skin Transplantation

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Last Updated: May 29, 2026

Tissue Characterization after a New Disaggregation Method for Skin Micro-Grafts Generation
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Tissue Characterization after a New Disaggregation Method for Skin Micro-Grafts Generation

Published on: March 4, 2016

Murine Full-thickness Skin Transplantation
07:59

Murine Full-thickness Skin Transplantation

Published on: January 2, 2017

  • Conservative treatments were ineffective, necessitating surgical intervention.

    • Implications:

    • Complete surgical excision and subsequent skin grafting successfully treated the extensive lesions.
    • The patient achieved a good postoperative outcome with no recurrence of the pyodermatic process.
    • This case highlights surgical management as a viable option for recalcitrant pyoderma chronica vegetans.