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Function of strawberry notch family genes in the zebrafish brain development

Ai Takano1, Riyo Zochi, Masahiko Hibi

  • 1Division of Anatomy and Neurobiology, Department of Physiology and Cell Biology, Kobe University Graduate School of Medicine, Kobe 650-0017, Japan. ai0926ta@med.kobe-u.ac.jp

The Kobe Journal of Medical Sciences
|September 23, 2011
PubMed

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Notch Signaling Pathway

The Notch signaling pathway is a major intracellular signaling pathway that is highly conserved over a broad spectrum of metazoan species. It stands unique from other intracellular signaling mechanisms in animals because notch protein itself acts as the receptor as well as the primary signaling molecule.
The Notch gene came into the limelight in 1914 after the discovery that its mutation in Drosophila melanogaster leads to a serrated (or "notched") wing margin phenotype. It was not until 1985...