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DDTRP: Database of Drug Targets for Resistant Pathogens
Jagadish Chandrabose Sundaramurthi1, Prabhakaran Ramanandan, Sridharan Brindha
1ICMR-Biomedical Informatics Centre, Tuberculosis Research Centre (ICMR), Chetpet, Chennai-600031, Tamil Nadu, India.
Bioinformation
|September 23, 2011
Summary
Drug resistance poses a significant public health threat, necessitating novel therapeutics. The Database of Drug Targets for Resistant Pathogens (DDTRP) offers vital information on drug resistance, targets, and alternative strategies for seven key pathogens.
Area of Science:
- Microbiology
- Pharmacology
- Bioinformatics
Background:
- Antimicrobial resistance (AMR) is a critical global health challenge, leading to untreatable infections.
- Multidrug-resistant (MDR) and extensively drug-resistant (XDR) pathogens complicate treatment options.
- There is an urgent requirement for the development of new antimicrobial agents.
Purpose of the Study:
- To introduce the Database of Drug Targets for Resistant Pathogens (DDTRP).
- To consolidate information on drug resistance, drug targets, and metabolic pathways.
- To identify potential alternative drug targets for combating resistant pathogens.
Main Methods:
- Compilation of data on drugs with reported resistance.
- Identification of drug targets and associated metabolic pathways.
- Systematic listing of alternative targets for seven selected pathogens.
Main Results:
- The DDTRP database provides comprehensive information on drug resistance.
- It includes details on drug targets, metabolic pathways, and alternative targets.
- The database covers data for seven significant pathogens.
Conclusions:
- The DDTRP serves as a valuable resource for researchers and clinicians.
- It facilitates the identification of novel therapeutic strategies against resistant pathogens.
- The database is freely accessible, promoting wider research and development efforts.
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