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Published on: December 27, 2016
Antibacterial potential of citral derivatives
Soni A Singh1, Yogesh A Potdar, Rasika S Pawar
1Advanced Research Laboratory in Natural and Synthetic Chemistry, Department of Biotechnology, V. G. Vaze College, Mumbai University, Mithagar Road, Mulund (E), Mumbai 400 0081, India.
Abstract:
Nine conjugated acid derivatives from monoterpene citral have been synthesized using ester, amide condensations, Wittig, Knoevenagel, Baylis-Hillman reactions and their antimicrobial activities were evaluated through disc diffusion and serial dilution methods. Several derivatives displayed interesting antimicrobial activity. Particularly, the Baylis-Hillman adducts 8-10 were found to have more potent antibacterial and antifungal activities than standard drugs namely chloramphenicol and nystatin respectively.
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