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Does electrocardiography at admission predict outcome in Crimean -Congo hemorrhagic fever?
Mehmet Birhan Yilmaz1, Aynur Engin, Gokhan Bektasoglu
1Department of Cardiology, Cumhuriyet University School of Medicine, 58140 Sivas, Turkey. mehmet.birhan.yilmaz@tkd.org.tr
Insights
Electrocardiography can predict mortality in Crimean-Congo hemorrhagic fever (CCHF). T-wave changes and bundle branch block on ECG indicate a higher risk of death in CCHF patients.
Area of Science:
- Cardiology
- Infectious Diseases
- Public Health
Background:
- Crimean-Congo hemorrhagic fever (CCHF) is a severe viral illness with high mortality.
- Understanding CCHF pathogenesis and mortality predictors is crucial.
Purpose of the Study:
- To identify electrocardiographic (ECG) parameters that predict mortality in CCHF patients.
- To assess the utility of ECG for risk stratification in CCHF.
Main Methods:
- Retrospective study of 49 confirmed CCHF cases in Turkey.
- ECG analysis using the Minnesota coding system by expert cardiologists.
Main Results:
- 18 of 49 patients died; survivors and non-survivors were similar in baseline characteristics.
- T-wave changes and bundle branch block were more common in non-survivors.
- ECG findings predicted death with high sensitivity and specificity.
Conclusions:
- Simple ECG at admission can aid in risk stratification for CCHF patients.
- ECG may serve as a valuable tool for early identification of high-risk CCHF cases.
Background & Objectives:
Crimean - Congo hemorrhagic fever is an acute viral hemorrhagic fever with considerable mortality. Despite increasing knowledge about hemorrhagic fever viruses, the pathogenesis of Crimean -Congo hemorrhagic fever and causes of death were not well described. We aimed to evaluate whether there were electrocardiographic parameters designating mortality among these patients.
Study Design:
This retrospective study was performed among confirmed Crimean -Congo hemorrhagic fever cases in Turkey. Electrocardiography was available in 49 patients within 24 h of hospitalization. All electrocardiograms were evaluated by two expert cardiologists according to Minnesota coding system.
Results:
Among patients with available electrocardiograms, there were 31 patients who survived, and 18 patients who died of Crimean - Congo hemorrhagic fever. Both groups were similar in terms of age, sex, body temperature, heart rate, and blood parameters. T-wave changes and bundle branch block were more frequently encountered among those who died. Presence of T-wave negativity or bundle branch block in this cohort of patients with Crimean -Congo hemorrhagic fever predicted death with a sensitivity of 72.7%, specificity of 92.6%, positive predictive value of 88.9%, negative predictive value of 80.6%.
Conclusions:
We think within the light of our findings that simple electrocardiography at admission may help risk stratification among Crimean-Congo hemorrhagic fever cases.
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