Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Progesterone as a bone-trophic hormone.

J C Prior1

  • 1Division of Endocrinology and Metabolism, University of British Columbia, Vancouver, Canada.

Endocrine Reviews
|May 1, 1990
PubMed
Summary
This summary is machine-generated.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Lack of evidence that progesterone in ovulatory cycles causes breast cancer.

Climacteric : the journal of the International Menopause Society·2023
Same author

Osteoporotic vertebral fracture (OVF): diagnosis requires an informed observer.

Osteoporosis international : a journal established as result of cooperation between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA·2022
Same author

The diagnosis of osteoporotic vertebral fractures redux.

Clinical radiology·2021
Same author

Where's the break? Critique of radiographic vertebral fracture diagnostic methods.

Osteoporosis international : a journal established as result of cooperation between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA·2021
Same author

Simulated effects of early menopausal bone mineral density preservation on long-term fracture risk: a feasibility study.

Osteoporosis international : a journal established as result of cooperation between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA·2021
Same author

Differences in fracture prevalence and in bone mineral density between Chinese and White Canadians: the Canadian Multicentre Osteoporosis Study (CaMos).

Archives of osteoporosis·2020
Same journal

Sex Hormones & Exercise in the Musculoskeletal System: From Signaling to Structure and Function.

Endocrine reviews·2026
Same journal

DAX-1 in sex determination and gonadal development: revisiting the anti-testis hypothesis.

Endocrine reviews·2026
Same journal

Regulators of Appetite in Mammals - Old and New players.

Endocrine reviews·2026
Same journal

Endometriosis-associated Pain: Mechanism, Neuroimmune Signature, and Translational Precision Strategies.

Endocrine reviews·2026
Same journal

Nuclear Receptors Shape Sepsis Pathophysiology.

Endocrine reviews·2026
Same journal

Beyond aldosterone and renin: emerging biomarkers for diagnosing and subtyping primary aldosteronism.

Endocrine reviews·2026
See all related articles

Progesterone plays a key role in bone metabolism, influencing bone formation and turnover. This suggests progesterone deficiency may contribute to postmenopausal osteoporosis.

Area of Science:

  • Endocrinology
  • Bone Biology
  • Reproductive Science

Background:

  • Progesterone's activity in bone metabolism is supported by experimental, epidemiological, and clinical data.
  • Progesterone may act directly on osteoblasts or indirectly via glucocorticoid receptors.

Purpose of the Study:

  • To review and analyze the role of progesterone in bone metabolism.
  • To explore the potential causal relationship between progesterone and bone remodeling.

Main Methods:

  • Review of existing experimental, epidemiological, and clinical data.
  • Analysis of the interplay between progesterone, estrogen, and bone remodeling cycles.
  • Integration of hormonal fluctuations within the ovulatory cycle with bone remodeling phases.

Related Experiment Videos

Main Results:

  • Progesterone appears to promote bone formation and increase bone turnover.
  • Progesterone may couple bone resorption with bone formation, particularly in conjunction with estrogen.
  • The ovulatory cycle's hormonal shifts align with phases of bone remodeling, suggesting a natural bone-activating cycle.

Conclusions:

  • Progesterone meets criteria to play a causal role in mineral metabolism.
  • Further research is needed on gonadal steroids' interaction with bone's life cycle.
  • Postmenopausal osteoporosis could be partly due to progesterone deficiency.