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Published on: February 9, 2019
Liposomal nanomedicine for breast cancer therapy
Shivani Rai Paliwal1, Rishi Paliwal, Govind P Agrawal
1Drug Delivery Research Laboratory, Department of Pharmaceutical Sciences, Dr. H. S. Gour Vishwavidyalaya, Sagar, M.P., India.
Abstract:
Liposomes are well-established nanocarriers for improving the therapeutic index of anticancer agents. A remarkable understanding in the pathophysiology of breast cancer progression has emerged with information on the involved specific biomolecules, which may serve as molecular targets for its therapy. Hormonal and nonhormonal receptors can both be exploited for targeting to breast cancer cells. Targeted delivery of cytotoxic drugs using liposomes is a novel approach for breast cancer therapy. In the present article, we summarize molecular targets present on the breast cancer cells. Recent developments in liposome-based delivery of bioactives for selective treatments of breast cancer are discussed. In addition, utilization of bioenvironmental conditions of tumor for liposome-based targeted delivery is also summed up.
Insights
Liposomes enhance anticancer drug delivery for breast cancer therapy by targeting specific molecular markers. This approach leverages tumor biology for more effective and selective cancer treatment.
Area of Science:
- Nanotechnology
- Oncology
- Pharmacology
Background:
- Breast cancer progression involves specific biomolecules acting as therapeutic targets.
- Liposomes are established nanocarriers for enhancing anticancer agent efficacy.
- Targeting breast cancer cells can utilize hormonal and nonhormonal receptors.
Purpose of the Study:
- To summarize molecular targets on breast cancer cells.
- To discuss recent advancements in liposome-based bioactive delivery for selective breast cancer treatment.
- To review the use of tumor bioenvironmental conditions for liposome-based targeted delivery.
Main Methods:
- Literature review of molecular targets in breast cancer.
- Analysis of liposome-based drug delivery systems.
- Exploration of targeting strategies utilizing cell receptors and tumor microenvironment.
Main Results:
- Identification of key molecular targets on breast cancer cells.
- Overview of liposome formulations for targeted delivery of anticancer agents.
- Discussion on exploiting tumor-specific conditions for enhanced liposome targeting.
Conclusions:
- Liposome-based targeted delivery offers a novel strategy for breast cancer therapy.
- Understanding breast cancer pathophysiology enables the development of specific molecular targets.
- Utilizing tumor bioenvironmental conditions can improve the selectivity of liposome delivery systems.
