Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Net Change Theorem01:22

Net Change Theorem

The Net Change Theorem is a fundamental principle in calculus that establishes a direct relationship between a function’s rate of change and its accumulated change over an interval. Mathematically, it states that the definite integral of a function's derivative over a given interval [a,b] yields the net change in the original function:This theorem has significant applications in various real-world scenarios, including physics, economics, and engineering. A particularly useful application is in...
Standard Entropy Change for a Reaction03:00

Standard Entropy Change for a Reaction

Entropy is a state function, so the standard entropy change for a chemical reaction (ΔS°rxn) can be calculated from the difference in standard entropy between the products and the reactants.
Alterations in Blood Pressure01:30

Alterations in Blood Pressure

Alterations in blood pressure, such as hypertension (high blood pressure) and hypotension (low blood pressure), significantly affect human health. Understanding these conditions' classifications, causes, and symptoms is essential for effective management and treatment.
Hypertension (High blood pressure)
Hypertension occurs when blood pressure readings consistently exceed the normal range. It is diagnosed when systolic blood pressure (the top number, indicating pressure while the heart beats)...
SI Units: 2019 Redefinition01:13

SI Units: 2019 Redefinition

Measurement is an indispensable part of analytical chemistry. The result of measurement helps quantify a substance's physical property and compare it with the physical property of another substance. Each measurement comprises two components - a number indicating the magnitude and a unit of measurement as a standard for comparison. Further, the same quantity can be measured using different units of measurement, which leads to differences in magnitude.
A standard set of units has been defined to...
FDA Approved Drugs: Changes to Approved Drugs01:26

FDA Approved Drugs: Changes to Approved Drugs

Post-approval, manufacturers may modify an approved new or generic drug product. Such modifications can encompass alterations in the Active Pharmaceutical Ingredient (API), manufacturing process, formulation, batch size, manufacturing site, and container closure system (FDA Guidance for Industry, April 2004). Often, a drug product may undergo multiple changes.These modifications require careful evaluation to determine their potential impact on the drug product's identity, strength, quality,...
Phase Changes01:19

Phase Changes

Phase transitions play an important theoretical and practical role in the study of heat flow. In melting or fusion, a solid turns into a liquid; the opposite process is freezing. In evaporation, a liquid turns into a gas; the opposite process is condensation.
A substance melts or freezes at a temperature called its melting point and boils or condenses at its boiling point. These temperatures depend on pressure. High pressure favors the denser form of the substance, so typically, high pressure...

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

[Detection of faecal blood outside organised screening programmes: the vital role of medical biologists].

Annales de biologie clinique·2026
Same author

Assessment of measurement uncertainty of immunoassays and LC-MS/MS methods for serum 25-hydroxyvitamin D.

Clinical chemistry and laboratory medicine·2025
Same author

Colorectal cancer screening in the UK: A public health intervention of unrealised potential.

Journal of medical screening·2025
Same author

Combining faecal haemoglobin, iron deficiency anaemia status and age can improve colorectal cancer risk prediction in patients attending primary care with bowel symptoms: a retrospective observational study.

Gut·2025
Same author

Correction to: Fecal Immunochemical Test Positivity Thresholds: An International Survey of Population‑Based Screening Programs.

Digestive diseases and sciences·2025
Same author

Fecal Immunochemical Test Positivity Thresholds: An International Survey of Population-Based Screening Programs.

Digestive diseases and sciences·2024
Same journal

Ethical evaluation of reflex and reflective testing in conformity with ISO 15189:2022 at the value-based laboratory medicine era.

Clinical chemistry and laboratory medicine·2026
Same journal

Emerging blood-based diagnostic strategies for tuberculosis.

Clinical chemistry and laboratory medicine·2026
Same journal

Homocitrulline and 3-year mortality in older hospitalised adults: an exploratory study.

Clinical chemistry and laboratory medicine·2026
Same journal

Impact of age partitioning on classification discordance in pediatric ferritin reference intervals.

Clinical chemistry and laboratory medicine·2026
Same journal

National implementation of LOINC: translation methodology and experience from the Polish laboratory terminology standardization project.

Clinical chemistry and laboratory medicine·2026
Same journal

Harmonization of measurement units: mission impossible or ethical imperative?

Clinical chemistry and laboratory medicine·2026
See all related articles

Related Experiment Video

Updated: May 29, 2026

Using Continuous Data Tracking Technology to Study Exercise Adherence in Pulmonary Rehabilitation
09:42

Using Continuous Data Tracking Technology to Study Exercise Adherence in Pulmonary Rehabilitation

Published on: November 8, 2013

Reference change values.

Callum G Fraser1

  • 1Centre for Research into Cancer Prevention and Screening, University of Dundee, Ninewells Hospital and Medical School, Dundee, Scotland, UK. callum.fraser@nhs.net

Clinical Chemistry and Laboratory Medicine
|October 1, 2011
PubMed
Summary
This summary is machine-generated.

Reference change values (RCV) offer objective assessment of serial test result differences using analytical imprecision and within-subject biological variation. RCV aids in delta-checking and auto-verification, though challenges remain in deriving values for all clinical quantities.

More Related Videos

Methods of Soil Resampling to Monitor Changes in the Chemical Concentrations of Forest Soils
09:16

Methods of Soil Resampling to Monitor Changes in the Chemical Concentrations of Forest Soils

Published on: November 25, 2016

Watershed Planning within a Quantitative Scenario Analysis Framework
12:44

Watershed Planning within a Quantitative Scenario Analysis Framework

Published on: July 24, 2016

Related Experiment Videos

Last Updated: May 29, 2026

Using Continuous Data Tracking Technology to Study Exercise Adherence in Pulmonary Rehabilitation
09:42

Using Continuous Data Tracking Technology to Study Exercise Adherence in Pulmonary Rehabilitation

Published on: November 8, 2013

Methods of Soil Resampling to Monitor Changes in the Chemical Concentrations of Forest Soils
09:16

Methods of Soil Resampling to Monitor Changes in the Chemical Concentrations of Forest Soils

Published on: November 25, 2016

Watershed Planning within a Quantitative Scenario Analysis Framework
12:44

Watershed Planning within a Quantitative Scenario Analysis Framework

Published on: July 24, 2016

Area of Science:

  • Clinical Chemistry
  • Laboratory Medicine
  • Biostatistics

Background:

  • Reference Change Values (RCV) are crucial for evaluating the significance of changes in serial laboratory test results.
  • Understanding analytical imprecision (CV(A)) and within-subject biological variation (CV(I)) is fundamental for RCV calculation.
  • CV(I) is generally stable across time, geography, methodology, and in stable health or disease states.

Purpose of the Study:

  • To highlight the importance and application of Reference Change Values (RCV) in clinical diagnostics.
  • To discuss the calculation and interpretation of RCV, including the role of the Z-score.
  • To identify challenges in RCV derivation and suggest potential solutions for broader clinical utility.

Main Methods:

  • The study outlines the formula for RCV calculation: RCV = 2(1/2) · Z · (CV(A)(2) + CV(I)(2))(1/2).
  • It emphasizes the correct interpretation of clinical semantics for appropriate Z-score selection.
  • Methods for deriving within-subject biological variation (CV(I)) are discussed, including challenges for certain clinical quantities.

Main Results:

  • RCV provides an objective tool for assessing the significance of differences in serial laboratory results.
  • Laboratory Information Management Systems (LIMS) can be adapted for RCV application in delta-checking and auto-verification.
  • Log-normal transformation has been recently employed for unidirectional RCV derivation.

Conclusions:

  • RCV is a vital concept for interpreting longitudinal laboratory data.
  • Further research is needed to fill knowledge gaps and derive RCV for all clinically important quantities.
  • Standardized guidelines increasingly emphasize the need for robust measures of change, underscoring the utility of RCV.