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Magnesium replacement therapy.

J R DiPalma1

  • 1Hahnemann University School of Medicine, Philadelphia, Pennsylvania.

American Family Physician
|July 1, 1990
PubMed
Summary
This summary is machine-generated.

Magnesium is crucial for enzymatic reactions and membrane potential. Disturbances like hypomagnesemia and hypermagnesemia require clinical assessment and can lead to serious health issues.

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Area of Science:

  • Biochemistry
  • Physiology
  • Clinical Medicine

Background:

  • Magnesium acts as a cofactor in numerous enzymatic reactions.
  • It plays a vital role in maintaining cellular membrane electric potential.
  • Magnesium balance is essential for overall physiological function.

Purpose of the Study:

  • To review the clinical significance of magnesium disturbances.
  • To highlight diagnostic challenges and common associations.
  • To outline the clinical manifestations and causes of altered magnesium levels.

Main Methods:

  • Clinical review of magnesium's role in human physiology.
  • Analysis of associations between magnesium levels and other electrolyte disturbances.
  • Examination of conditions leading to magnesium deficiency or excess.

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Main Results:

  • Hypomagnesemia often coexists with hypokalemia and hypocalcemia.
  • Hypermagnesemia is commonly observed in patients with renal failure.
  • Magnesium disturbances manifest with neuromuscular, CNS, and cardiac symptoms.

Conclusions:

  • Diagnosis of magnesium imbalances often relies on clinical judgment.
  • Inadequate intake, renal failure, and certain medical conditions contribute to magnesium disturbances.
  • Both deficiency and excess of magnesium can lead to severe clinical complications.