Poly-є-caprolactone based formulations for drug delivery and tissue engineering: A review
Tapan K Dash1, V Badireenath Konkimalla
1National Institute of Science Education and Research, Institute of Physics Campus, Sainik School, Sachivalaya marg, Bhubaneswar-751005, India.
Summary
Poly-є-caprolactone (PCL) is a versatile biodegradable polymer used in advanced drug delivery systems and tissue engineering. This review details various PCL formulations, their therapeutic applications, and preparation methods.
Area of Science:
- Biomaterials Science
- Polymer Chemistry
- Drug Delivery
Background:
- Biodegradable polymers offer improved therapeutic efficacy and pharmacokinetics for drug delivery.
- Poly-є-caprolactone (PCL) is a synthetic biodegradable polymer known for its low glass transition temperature and melting point.
- PCL's adaptable properties make it suitable for diverse drug delivery and tissue engineering applications.
Purpose of the Study:
- To review current drugs incorporated into poly-є-caprolactone (PCL) based formulations.
- To summarize the therapeutic purposes and outcomes of these PCL formulations.
- To categorize PCL formulations based on their preparation methods.
Main Methods:
- Literature review of PCL-based drug delivery systems and tissue engineering applications.
- Categorization of PCL formulations (microspheres, nanoparticles, scaffolds, etc.) by preparation technique.
- Analysis of incorporated drugs, their intended use, and reported results.
Main Results:
- PCL has been extensively investigated in various drug delivery systems and tissue engineering scaffolds.
- Diverse PCL formulations, including microspheres, nanoparticles, films, and fibers, have been developed.
- The review provides an updated overview of drugs utilized within these PCL matrices and their associated outcomes.
Conclusions:
- Poly-є-caprolactone (PCL) is a highly adaptable biodegradable polymer for advanced therapeutic applications.
- The diverse range of PCL formulations highlights its potential in both drug delivery and tissue regeneration.
- Further research into PCL-based systems promises enhanced treatment strategies.
Related Concept Videos
01:24Site-Targeted Drug Delivery Systems: Polymeric Carriers
Polymeric carriers enhance targeted drug delivery by increasing efficacy while minimizing off-target effects. These carriers comprise a biodegradable polymeric backbone integrated with functional elements that enable targeting, improve physicochemical properties, and regulate drug release.Targeting MechanismsThe targeting ability of polymeric carriers is mediated by a homing device, which is a molecular recognition component designed to selectively bind to specific tissues or cells. Monoclonal...
01:19Modified-Release Drug Delivery Systems: Rate-Programmed II
Rate-programmed drug delivery systems release drugs in a controlled manner to maintain therapeutic levels. Three main designs include reservoir, matrix, and hybrid systems.Reservoir systems consist of a drug core enclosed within a membrane that controls drug release. In non-swelling reservoir systems, polymers like ethyl cellulose or polymethacrylates are used. These do not hydrate in aqueous media and control release through membrane thickness, porosity, or insolubility. This type includes...
01:23Modified-Release Drug Delivery Systems: Classification
Modified-release drug delivery systems improve drug efficacy and minimize side effects by controlling the rate and location of drug release. These systems fall into three categories: rate-programmed, stimuli-activated, and site-targeted.Rate-programmed systems release drugs at a predetermined rate, maintaining consistent therapeutic levels and reducing fluctuations that could lead to toxicity or subtherapeutic effects. These systems use polymeric matrices, reservoir-based designs, or osmotic...
01:11Oral Drug Delivery Systems: Delayed-Release Systems
Delayed-release drug delivery systems are specialized pharmaceutical formulations designed to postpone the release of active compounds until the drug reaches a specific region of the gastrointestinal (GI) tract, typically the intestine. These systems are essential for drugs that may cause gastric irritation, are unstable in acidic environments, or need to exert therapeutic effects locally in the intestinal or colonic regions.The core feature of delayed-release systems is the use of enteric...
01:24Modified-Release Drug Delivery Systems: Site-Targeted
Site-targeted drug delivery systems enhance therapeutic efficacy while minimizing systemic toxicity and treatment costs. Unlike conventional methods, these systems ensure precise drug delivery, improving bioavailability and reducing side effects. Targeted drug delivery is classified into three levels. First-order targeting directs drugs to the capillary beds of specific organs or tissues. Second-order targets specific cell types, such as tumor cells, using receptor-mediated interactions.
01:05Bioavailability Enhancement: Drug Stability Enhancement and GI Retention
Improving a drug's stability in the gastrointestinal (GI) tract is paramount for enhancing its bioavailability and therapeutic effectiveness. Various strategies are employed to protect the drug from the harsh gastric milieu and to ensure its release and absorption at the desired site within the GI tract.Polymer coatings are one such method used to shield drugs from the stomach's acidic environment. By preventing premature drug release, these coatings improve the bioavailability of unstable...