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Updated: May 28, 2026

System for Efficacy and Cytotoxicity Screening of Inhibitors Targeting Intracellular Mycobacterium tuberculosis
Published on: April 5, 2017
Automated quantitative drug susceptibility testing of non-tuberculous mycobacteria using MGIT 960/EpiCenter TB eXiST
Katja Lucke1, Michael Hombach, Ute Friedel
1Institut für Medizinische Mikrobiologie, Universität Zürich, Nationales Zentrum für Mykobakterien, Zürich, Switzerland.
Objectives:
To assess the predictive value of in vitro drug susceptibility testing (DST) in slow-growing non-tuberculous mycobacteria (NTM), knowledge on quantitative levels of drug susceptibility should be available. The aim of this study was to investigate the suitability of the MGIT 960/TB eXiST system for quantitative DST of NTM.
Methods:
We have assessed quantitative levels of drug susceptibility for clinical isolates of Mycobacterium avium, Mycobacterium intracellulare and Mycobacterium kansasii by comparing radiometric Bactec 460TB-based DST with non-radiometric DST using MGIT 960/TB eXiST.
Results:
MGIT 960/TB eXiST gives results comparable to those of Bactec 460TB.
Conclusions:
The MGIT 960/TB eXiST appears suitable for quantitative DST of NTM.
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