Search research articles

ABOUT JoVE

Overview Leadership Blog JoVE Help Center

AUTHORS

Publishing Process Editorial Board Scope & Policies Peer Review FAQ Submit

LIBRARIANS

Testimonials Subscriptions Access Resources Library Advisory Board FAQ

RESEARCH

JoVE Journal Methods Collections JoVE Encyclopedia of Experiments Archive

EDUCATION

JoVE Core JoVE Business JoVE Science Education JoVE Lab Manual Faculty Resource Center Faculty Site

Terms & Conditions of Use

Related Concept Videos

Aging

Aging

Aging is a complex biological phenomenon influenced by various processes that affect cellular and systemic functions. Several prominent theories attempt to explain its mechanisms, highlighting cellular limitations, oxidative damage, and hormonal changes as central factors in aging.
Cellular Clock Theory
The cellular clock theory posits that the human lifespan is closely tied to the finite capacity of cells to divide, a phenomenon governed by telomeres, which are protective caps at the ends of...

Mitochondria

Mitochondria

Mitochondria are eukaryotic cellular organelles that are known to produce energy through a process called oxidative phosphorylation. Besides their primary function, mitochondria are involved in various cellular processes, including cell growth, differentiation, signaling, metabolism, and senescence. Age-related changes cause a decline in mitochondrial quality and integrity due to increased mitochondrial mutations and oxidative damage. Thus, aging can severely impact mitochondrial functions,...

Electron Transport Chain: Complex I and II

Electron Transport Chain: Complex I and II

The mitochondrial electron transport chain (ETC) is the main energy generation system in the eukaryotic cells. However, mitochondria also produce cytotoxic reactive oxygen species (ROS) due to the large electron flow during oxidative phosphorylation. While Complex I is one of the primary sources of superoxide radicals, ROS production by Complex II is uncommon and may only be observed in cancer cells with mutated complexes.
ROS generation is regulated and maintained at moderate levels necessary...

The Effect of Aging on Tissues

The Effect of Aging on Tissues

Several body functions deteriorate with age. The external signs of aging are easily identifiable. For example, the skin becomes dry, less elastic, and thins out, forming wrinkles. The skin of the face begins to appear looser due to a decrease in the levels of elastic and collagen fibers in the connective tissue. Additionally, melanin production in the hair follicle decreases with age, resulting in gray hair. Moreover, the senses of sight and hearing decline, so glasses and hearing aids may...

Electron Transport Chain: Complex III and IV

Electron Transport Chain: Complex III and IV

During the electron transport chain, electrons from NADH and FADH2 are first transferred to complexes I and II, respectively. These two complexes then transfer the electrons to ubiquinol, which carries them further to complex III. Complex III passes the electrons across the intermembrane space to Cyt c, which carries them further to complex IV. Complex IV donates electrons to oxygen and reduces it to water. As electrons pass through complexes I, III, and IV, the energy released aids the pumping...

Mitochondrial Membranes

Mitochondrial Membranes

A single mitochondrion is a bean-shaped organelle enclosed by a double-membrane system. The outer membrane of mitochondria is smooth and contains many porins - the integral membrane transporters. Porins enable free diffusion of ions and small uncharged molecules through the outer mitochondrial membrane but limit the transport of molecules larger than 5000 Daltons. Further, the outer mitochondrial membrane forms a unique structure called membrane contact sites with other subcellular organelles,...

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by

Same author

Hybrid-regime Doppler Lidar for atmospheric wind profiling: development and performance assessment.

Optics express·2026

Same author

Preparation and performance evaluation of a novel Tween 80-based microemulsion system for the remediation of petroleum hydrocarbon-contaminated soil using soil washing test.

Environmental research·2026

Same author

Microemulsion flushing of petroleum hydrocarbons in porous media: Microfluidic insights into residual oil morphologies and removal mechanisms.

Journal of environmental management·2026

Same author

Spatially Proximate Acid Sites in Zeolites Synergistically Boost Alkane Activation.

Angewandte Chemie (International ed. in English)·2026

Same author

Flat band induced quasi-one-dimensional magnon transport in a two-dimensional spin lattice.

Nature communications·2026

Same author

Advancing Early Detection of PCI-Related Renal Injury Based on Novel Biomarkers in Patients With Acute Coronary Syndrome.

Kardiologiia·2026

Same journal

Thyroid Hormones as Renal Cell Cancer Regulators.

Journal of signal transduction·2016

Same journal

Analysis of AKAP7γ Dimerization.

Journal of signal transduction·2015

Same journal

Phosphatase and Tensin Homologue: Novel Regulation by Developmental Signaling.

Journal of signal transduction·2015

Same journal

Signaling pathways involved in renal oxidative injury: role of the vasoactive peptides and the renal dopaminergic system.

Journal of signal transduction·2014

Same journal

Signaling Network Map of Endothelial TEK Tyrosine Kinase.

Journal of signal transduction·2014

Same journal

TGF- β Signaling Cooperates with AT Motif-Binding Factor-1 for Repression of the α -Fetoprotein Promoter.

Journal of signal transduction·2014

See all related articles

Search research articles

Related Experiment Video

Updated: May 28, 2026

Ratiometric Biosensors that Measure Mitochondrial Redox State and ATP in Living Yeast Cells

Ratiometric Biosensors that Measure Mitochondrial Redox State and ATP in Living Yeast Cells

Published on: July 22, 2013

Oxidative stress, mitochondrial dysfunction, and aging.

Hang Cui¹, Yahui Kong, Hong Zhang

¹Department of Cell Biology, University of Massachusetts Medical School, Worcester, MA 01655, USA.

Journal of Signal Transduction

|October 7, 2011

Summary

This summary is machine-generated.

Aging involves mitochondrial damage from reactive oxygen species (ROS). This study explores the link between ROS, mitochondria, and aging, impacting age-related diseases.

More Related Videos

Imaging of mtHyPer7, a Ratiometric Biosensor for Mitochondrial Peroxide, in Living Yeast Cells

Imaging of mtHyPer7, a Ratiometric Biosensor for Mitochondrial Peroxide, in Living Yeast Cells

Published on: June 2, 2023

Related Experiment Videos

Last Updated: May 28, 2026

Ratiometric Biosensors that Measure Mitochondrial Redox State and ATP in Living Yeast Cells

Ratiometric Biosensors that Measure Mitochondrial Redox State and ATP in Living Yeast Cells

Published on: July 22, 2013

Imaging of mtHyPer7, a Ratiometric Biosensor for Mitochondrial Peroxide, in Living Yeast Cells

Imaging of mtHyPer7, a Ratiometric Biosensor for Mitochondrial Peroxide, in Living Yeast Cells

Published on: June 2, 2023

Area of Science:

Gerontology and Molecular Biology

Background:

Aging is a complex process involving physiological decline and increased disease risk.
The molecular drivers of aging are not fully understood.
Mitochondrial and free-radical theories implicate oxidative damage in aging.

Purpose of the Study:

To elucidate the intricate relationship between reactive oxygen species (ROS) and mitochondria in the aging process.
To discuss the potential role of this interplay in the development of age-related diseases.

Main Methods:

Review of current scientific literature on ROS and mitochondrial function in aging.
Analysis of proposed mechanisms linking oxidative damage to mitochondrial dysfunction.

Main Results:

Reactive oxygen species (ROS) cause cumulative damage to mitochondria and mitochondrial DNA (mtDNA).
This oxidative damage impairs mtDNA replication and transcription, leading to reduced mitochondrial function.
Compromised mitochondrial function can exacerbate ROS production, creating a damaging cycle.

Conclusions:

The interplay between ROS and mitochondria is a significant factor in aging.
Understanding this relationship is crucial for addressing age-related pathologies.