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Related Concept Videos

Skin Cancer01:30

Skin Cancer

Skin cancer is a type of cancer that occurs when there is an abnormal growth of skin cells, usually triggered by damage to the DNA within the skin cells. It is primarily caused by exposure to ultraviolet (UV) radiation from the sun or artificial sources like tanning beds. Skin cancer is the most common type of cancer worldwide, and its incidence continues to rise.
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Acne Infection

Acne is a multifactorial skin condition primarily affecting adolescents and young adults, with a global prevalence estimated to exceed 75% in this demographic. The condition is characterized by the formation of comedones (blackheads and whiteheads), papules, pustules, nodules, and, in severe cases, cysts, particularly in areas rich in sebaceous glands such as the face, neck, chest, and back. The pathogenesis involves increased sebum production, follicular hyperkeratinization, colonization by...
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Changes in Skin Color: Clinical Perspectives

The first thing a clinician sees is the skin, so the examination of the skin should be part of any thorough physical examination. Most skin disorders are relatively benign, but a few, including melanomas, can be fatal if untreated. A couple of the more noticeable disorders, albinism and vitiligo, affect the appearance of the skin and its accessory organs.
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Management of Insomnia

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Roller Microneedle Combined with Tranexamic Acid Solution in Treating Melasma
04:12

Roller Microneedle Combined with Tranexamic Acid Solution in Treating Melasma

Published on: January 19, 2024

Melasma: treatment strategy.

Virendra N Sehgal1, Prashant Verma, Govind Srivastava

  • 1Dermato Venereology Center, Sehgal Nursing Home, Panchwati, Delhi, India. drsehgal@ndf.vsnl.net.in

Journal of Cosmetic and Laser Therapy : Official Publication of the European Society for Laser Dermatology
|October 11, 2011
PubMed
Summary
This summary is machine-generated.

Melasma is a common facial hyperpigmentation, particularly in women with darker skin. Treatment involves sun protection and various agents, with combination therapies showing enhanced efficacy.

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Area of Science:

  • Dermatology
  • Cosmetic Science

Background:

  • Melasma is a prevalent facial hyperpigmentation affecting middle-aged women, especially those with darker complexions.
  • Its exact cause is unknown, but factors like genetics, sun exposure, hormonal influences, and certain medications are implicated.
  • Recognized patterns include centro-facial, malar, and mandibular, with epidermal pigmentation appearing brown/black and dermal appearing blue, distinguishable by Wood's lamp.

Purpose of the Study:

  • To review the understanding of melasma's pathogenesis and current treatment modalities.
  • To highlight the role of increased melanin and tyrosinase-related protein-1 in melasma development.
  • To discuss the efficacy of various therapeutic approaches, including monotherapy and combination treatments.

Main Methods:

  • Literature review of melasma pathogenesis and treatment options.
  • Analysis of clinical observations regarding different melasma types and skin tones.
  • Evaluation of the effectiveness of various lightening agents and procedures.

Main Results:

  • Melasma involves increased melanin in the epidermis and/or dermis, with elevated tyrosinase-related protein-1 expression.
  • Broad-spectrum sunscreen is crucial for management.
  • Combination therapies (e.g., hydroquinone, tretinoin, corticosteroids) appear more effective than monotherapy.

Conclusions:

  • Melasma management requires a multi-faceted approach including sun protection and targeted treatments.
  • Various agents like retinoic acid, azelaic acid, and novel compounds show potential.
  • Adjunctive therapies such as chemical peels and laser treatments can be beneficial.