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Updated: May 28, 2026
07:50
Establishment of a Clinic-based Biorepository
Published on: May 29, 2017
Saurian papulosis: a new clinicopathological entity
Ana María Molina-Ruiz1, María del Carmen Fariña, Loreto Carrasco
1Department of Dermatology, Fundación Jiménez Díaz, Universidad Autónoma, Madrid, Spain.
Journal of the American Academy of Dermatology
|October 11, 2011
Summary
A new skin condition, saurian papulosis, is described, characterized by unusual epidermal keratinization. This disorder presents as widespread, symmetric, erythematous papules with fine scaling, distinct from other keratinization disorders.
Area of Science:
- Dermatology
- Pathology
- Genetics
Background:
- Epidermal keratinization disorders are a diverse group of skin diseases.
- Abnormal epidermal maturation and stratum corneum disturbance are common features.
Observation:
- Two unrelated patients presented with a long-standing, widespread cutaneous eruption.
- The eruption featured symmetric, erythematous, flat, polygonal papules with fine scaling, affecting most of the skin surface.
- No facial, mucosal, nail, or palmoplantar involvement was noted; teeth and hair were normal.
Findings:
- Histopathology revealed orthokeratotic hyperkeratosis overlying acanthotic epidermis.
- Lesional skin exhibited weaker immunoexpression for connexin 43 compared to normal skin.
- The condition appeared to have a familial component in both cases.
Implications:
- This study describes a novel clinicopathologic entity, termed "saurian papulosis."
- Further investigation is needed to understand the full spectrum and genetic basis of this disorder.
- The findings contribute to the understanding of epidermal keratinization disorders.
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