Estrogens and obesity: is it all in our heads?
Sarah Hart-Unger1, Kenneth S Korach
1Pediatric Endocrinology, Duke University Medical Center, Durham, NC 27710, USA.
Cell Metabolism
|October 11, 2011
Abstract
None:
Estrogens have preventative effects on weight gain and associated comorbidities, but the tissue-specific targets remain unknown. Here, Xu et al. (2011) demonstrate that ablation of estrogen signaling in two populations of hypothalamic neurons leads to weight gain and subsequent metabolic dysregulation and could be important target sites of estrogen actions.
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