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Related Experiment Videos

Preference for diazepam in anxious adults.

S G McCracken1, H de Wit, E H Uhlenhuth

  • 1School of Social Service Administration, University of Chicago, Illinois 60637.

Journal of Clinical Psychopharmacology
|June 1, 1990
PubMed
Summary

Anxious adults rarely preferred diazepam (Valium) over placebo in a blind choice study. Subjective effects varied, with frequent choosers reporting less anxiety and more stimulation.

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Area of Science:

  • Psychopharmacology
  • Clinical Psychology

Background:

  • Generalized anxiety disorder (GAD) affects many adults.
  • Effective pharmacological treatments are crucial for managing anxiety disorders.

Purpose of the Study:

  • To determine if anxious adults prefer diazepam (Valium) over placebo.
  • To examine the relationship between subjective drug effects and choice behavior.

Main Methods:

  • Double-blind, placebo-controlled choice experiment.
  • Nine-session study with 14 GAD volunteers.
  • Subjects sampled diazepam 10 mg and placebo, then made choices.

Main Results:

  • Only 3 of 14 subjects consistently chose diazepam.
  • Most subjects chose placebo or alternated.

Related Experiment Videos

  • Frequent diazepam choosers reported reduced anxiety and increased stimulation; infrequent choosers reported increased confusion.

    • Conclusions:

    • Anxious adults generally do not prefer diazepam over placebo in a blind choice paradigm.
    • Subjective responses to diazepam are heterogeneous and may predict choice behavior.