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Updated: May 28, 2026

Administration of Δ9-Tetrahydrocannabinol (THC) in Adolescent and Adult Mice
Published on: August 1, 2025
Cannabis in sport: anti-doping perspective
Marilyn A Huestis1, Irene Mazzoni, Olivier Rabin
1Chemistry and Drug Metabolism, Intramural Research Program, National Institute on Drug Abuse, National Institutes of Health, Baltimore, MD 21224, USA. mhuestis@intra.nida.nih.gov
Cannabinoids remain prohibited in sports due to performance enhancement concerns, health risks, and violating the spirit of sport. Understanding cannabinoid pharmacology is crucial for anti-doping efforts.
Area of Science:
- Sports Science
- Pharmacology
- Anti-Doping
Background:
- Cannabinoids have been prohibited in sports by the World Anti-Doping Agency since 2004.
- The World Anti-Doping Code outlines criteria for banning substances, including cannabinoids.
Purpose of the Study:
- To review the rationale behind the prohibition of cannabinoids in sports.
- To discuss the potential for cannabis to enhance athletic performance.
- To examine health risks and the spirit of sport implications.
Main Methods:
- Review of the World Anti-Doping Code and established criteria for prohibited substances.
- Analysis of current knowledge on cannabinoid pharmacology and pharmacokinetics.
- Discussion of the impact of Δ(9)-tetrahydrocannabinol on anti-doping rule violations.
Main Results:
- Cannabinoids are prohibited in-competition due to potential performance enhancement, health risks, and violation of the spirit of sport.
- The pharmacokinetics of Δ(9)-tetrahydrocannabinol present challenges in managing positive anti-doping tests.
- Passive inhalation is unlikely to cause a positive test result.
Conclusions:
- The prohibition of cannabinoids in sports is supported by evolving scientific understanding of their effects.
- Continued research into cannabinoid pharmacology is essential for informed anti-doping policies.
- Addressing the complexities of cannabinoid detection and interpretation remains a key challenge.
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