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Blood pressure elevation in long-term survivors of pediatric liver transplantation

V A McLin1, R Anand, S R Daniels

  • 1Department of Pediatrics, University Hospitals Geneva, Switzerland. valerie.mclin@hcuge.ch

American Journal of Transplantation : Official Journal of the American Society of Transplantation and the American Society of Transplant Surgeons
|October 14, 2011
PubMed

Insights

Pediatric liver transplant (LT) survivors frequently experience elevated blood pressure (BP) between 5-10 years post-transplant. Factors like transplant age, steroid use, and kidney function impact BP outcomes.

Area of Science:

  • Pediatric Nephrology
  • Transplant Medicine
  • Cardiovascular Health

Background:

  • Long-term immunosuppression in pediatric liver transplant (LT) recipients can lead to chronic medical issues.
  • Understanding the long-term complications, particularly cardiovascular health, is crucial as these patients mature.

Purpose of the Study:

  • To determine the prevalence of elevated blood pressure (BP) in long-term pediatric LT survivors.
  • To identify factors that predict elevated BP in this population.

Main Methods:

  • Utilized data from the Studies in Pediatric Liver Transplantation (SPLIT) database.
  • Analyzed BP measurements from 815 patients 5-10 years post-LT.
  • Employed multivariate analysis to identify predictive factors for elevated BP.

Main Results:

  • Prevalence of elevated BP ranged from 17.5% to 27.5% between 5-10 years post-LT.
  • 62.5% of patients had at least one additional elevated BP reading during follow-up.
  • Predictive factors for elevated BP included age at transplant, steroid use, and estimated glomerular filtration rate (eGFR).

Conclusions:

  • Pediatric LT recipients exhibit a significant prevalence of elevated BP years after transplantation.
  • Elevated BP is associated with specific factors including age at transplant, reduced kidney function, and recent steroid use.

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