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Integrins and other cell adhesion molecules.

S M Albelda1, C A Buck

  • 1Wistar Institute, Philadelphia, Pennsylvania 19104.

FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology
|August 1, 1990
PubMed
Summary
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Cell adhesion receptors like integrins mediate cell interactions, influencing growth, differentiation, and tissue repair. This review highlights their structure, function, and roles in development, inflammation, and disease.

Area of Science:

  • Cell biology
  • Molecular biology
  • Biochemistry

Background:

  • Cell-cell and cell-substratum interactions are crucial for multicellular organisms.
  • These interactions are mediated by various families of adhesion receptors.
  • These receptors regulate fundamental cellular processes beyond adhesion.

Purpose of the Study:

  • To review recent data on the structure and function of cell adhesion molecules.
  • To emphasize the role of the integrin family.
  • To discuss the involvement of these molecules in various physiological and pathological processes.

Main Methods:

  • Literature review of recent scientific data.
  • Focus on integrin structure and function.
  • Synthesis of information on adhesion molecule roles.

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Main Results:

  • Identified five main families of adhesion receptors: integrins, immunoglobulin superfamily, cadherins, LEC-CAMs, and homing receptors.
  • Highlighted the diverse functions of these receptors, including growth, differentiation, and polarity.
  • Detailed the specific roles of integrins in cell adhesion.

Conclusions:

  • Cell adhesion molecules are critical regulators of cellular processes.
  • Integrins play a significant role in development, inflammation, wound healing, coagulation, and metastasis.
  • Further research into these molecules can provide insights into disease mechanisms.