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Expression and Purification of Virus-like Particles for Vaccination
Published on: June 2, 2016
Pandemic influenza vaccines - the challenges
Lars R Haaheim1, Abdullah S Madhun, Rebecca Cox
1Myrdalskogen 95, N-5117 Ulset, Norway.
Abstract:
Recent years' enzootic spread of highly pathogenic H5N1 virus among poultry and the many lethal zoonoses in its wake has stimulated basic and applied pandemic vaccine research. The quest for an efficacious, affordable and timely accessible pandemic vaccine has been high on the agenda. When a variant H1N1 strain of swine origin emerged as a pandemic virus, it surprised many, as this subtype is well-known to man as a seasonal virus. This review will cover some difficult vaccine questions, such as the immunological challenges, the new production platforms, and the limited supply and global equity issues.
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