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Related Concept Videos

Chronic Inflammation: Introduction01:12

Chronic Inflammation: Introduction

Chronic inflammation is a prolonged, dysregulated immune response that persists for weeks to years when the inciting stimulus is difficult to eradicate or when self‑antigens drive ongoing reactivity. Morphologically, it is defined by mononuclear cell infiltration, progressive tissue destruction, and concurrent attempts at healing via angiogenesis and fibrosis. Compared with acute inflammation, edema is less prominent while cellular infiltration predominates; triggers include persistent...
Inflammatory Bowel Disease III: Crohn's Disease01:25

Inflammatory Bowel Disease III: Crohn's Disease

Crohn’s disease is a chronic, relapsing form of inflammatory bowel disease characterized by segmental, transmural inflammation that can affect any part of the gastrointestinal tract. Its pathogenesis arises from a combination of genetic susceptibility, environmental exposures, epithelial barrier dysfunction, and immune dysregulation. Together, these factors lead to an exaggerated immune response against components of the gut microbiome.Genetic and Environmental InfluencesMultiple genetic...
The Tumor Microenvironment02:17

The Tumor Microenvironment

Every normal cell or tissue is embedded in a complex local environment called stroma, consisting of different cell types, a basal membrane, and blood vessels. As normal cells mutate and develop into cancer cells, their local environment also changes to allow cancer progression. The tumor microenvironment (TME) consists of a complex cellular matrix of stromal cells and the developing tumor. The cross-talk between cancer cells and surrounding stromal cells is critical to disrupt normal tissue...
Psychoneuroimmunology: Diabetes and Cancer01:19

Psychoneuroimmunology: Diabetes and Cancer

Chronic stress has been linked to both the onset and progression of serious health conditions, including Type 2 diabetes and cancer. Type 2 diabetes, a widespread chronic illness, is closely associated with obesity and insulin resistance, both of which often worsen under stress. Studies indicate that men experiencing high levels of chronic stress face a 45% higher risk of developing diabetes compared to those with minimal stress. Stress triggers physiological responses that elevate blood...
Tumor Immunotherapy01:27

Tumor Immunotherapy

Immunotherapy is a treatment that boosts or manipulates the immune system to fight diseases, including cancer. For instance, by stimulating an immune response through vaccinations against viruses that cause cancers, like hepatitis B virus and human papillomavirus, these diseases can be prevented. Nonetheless, some cancer cells can avoid the immune system due to their rapid mutation and division. The immune response to many cancers involves three phases: elimination, equilibrium, and escape.
Chronic Bowel Disorders: Introduction01:17

Chronic Bowel Disorders: Introduction

Chronic bowel diseases are a group of long-term conditions affecting the digestive tract, characterized by inflammation and damage to the gut lining. These conditions primarily include irritable bowel syndrome and inflammatory bowel disease.
Irritable Bowel Syndrome (IBS) is a common disorder affecting the gastrointestinal tract. The distinctive feature is recurrent abdominal pain associated with altered bowel movements, manifesting as constipation, diarrhea, or fluctuating between both. The...

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Related Experiment Video

Updated: May 28, 2026

Studying the Effects of Tumor-Secreted Paracrine Ligands on Macrophage Activation using Co-Culture with Permeable Membrane Supports
07:44

Studying the Effects of Tumor-Secreted Paracrine Ligands on Macrophage Activation using Co-Culture with Permeable Membrane Supports

Published on: November 28, 2019

Chronic inflammation and immunologic-based constraints in malignant disease.

Devin B Lowe1, Walter J Storkus

  • 1Department of Dermatology, University of Pittsburgh School of Medicine, Pittsburgh, PA 15213, USA.

Immunotherapy
|October 15, 2011
PubMed
Summary

Chronic inflammation promotes cancer development. Strategies to resolve inflammation and boost acute immune responses may reduce cancer incidence and improve treatment outcomes by enhancing survival and quality of life.

Related Experiment Videos

Last Updated: May 28, 2026

Studying the Effects of Tumor-Secreted Paracrine Ligands on Macrophage Activation using Co-Culture with Permeable Membrane Supports
07:44

Studying the Effects of Tumor-Secreted Paracrine Ligands on Macrophage Activation using Co-Culture with Permeable Membrane Supports

Published on: November 28, 2019

Area of Science:

  • Immunology and Cancer Biology
  • Inflammation and Disease Pathogenesis

Background:

  • Acute inflammation is a vital host defense mechanism crucial for pathogen clearance and tissue repair.
  • Unresolved inflammation can become chronic, creating a pro-tumorigenic microenvironment that drives cancer development and progression.

Purpose of the Study:

  • To explore the dual role of inflammation in cancer: its protective acute phase and its detrimental chronic phase.
  • To investigate therapeutic strategies targeting chronic inflammation and promoting acute immunity for cancer prevention and treatment.

Main Methods:

  • Review of existing literature on inflammatory pathways in cancer.
  • Analysis of the molecular mechanisms linking chronic inflammation to oncogenesis.
  • Conceptualization of combinational therapies integrating anti-inflammatory and immunomodulatory approaches.

Main Results:

  • Chronic inflammation is a significant risk factor for cancer initiation and progression.
  • Restoring acute inflammatory responses and resolving chronic inflammation are potential strategies for cancer intervention.
  • Combined therapies disrupting chronic inflammation and enhancing adaptive immunity show promise for improving patient outcomes.

Conclusions:

  • Modulating the host's inflammatory state, shifting from chronic to acute, is a promising avenue for cancer prevention.
  • Targeting chronic inflammation alongside boosting specific immune responses offers a novel therapeutic strategy for cancer treatment, potentially improving survival and quality of life.