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Characterizing the Composition of Molecular Motors on Moving Axonal Cargo Using "Cargo Mapping" Analysis

Characterizing the Composition of Molecular Motors on Moving Axonal Cargo Using "Cargo Mapping" Analysis

Published on: October 30, 2014

Prions on the move.

Charles Weissmann¹, Jiali Li, Sukhvir P Mahal

¹Department of Infectology, Scripps Florida, 130 Scripps Way, Jupiter, Florida 33458, USA. charlesw@scripps.edu

|October 15, 2011

Summary

This summary is machine-generated.

Prion diseases involve PrP(Sc) aggregates, which exist as diverse strains with varying conformations. These prion populations act as quasi-species, with specific conformers selected for efficient replication in different environments, influencing transmission and drug resistance.

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High-throughput Screening for Protein-based Inheritance in S. cerevisiae

High-throughput Screening for Protein-based Inheritance in S. cerevisiae

Published on: August 8, 2017

Area of Science:

Neuroscience
Molecular Biology
Prion Biology

Background:

Prions are infectious proteins, primarily composed of aggregated PrP(Sc) conformers of the host PrP(C).
Prions exhibit strain diversity, characterized by distinct conformations despite originating from the same PrP(C) sequence.
Prion transmission dynamics suggest evolutionary processes like mutation and selection.

Purpose of the Study:

To investigate the concept of prion populations as quasi-species.
To explain the mechanisms behind prion strain variation, interspecies transmission efficiency, and drug resistance.

Main Methods:

The study proposes a theoretical framework based on existing prion research and experimental observations.
Analysis of prion behavior under different conditions, including interspecies transmission and drug exposure.

Main Results:

Prion populations contain a variety of conformers, analogous to viral quasi-species.
Environmental factors, such as host species or drug presence, select for specific prion conformers.
This selection process influences prion transmissibility and the emergence of drug-resistant variants.

Conclusions:

Prion propagation is driven by the selection of the most fit conformers within a quasi-species population.
This quasi-species model provides a unified explanation for prion strain diversity, adaptation, and resistance.